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Mol Microbiol

Title:		A Candida albicans-specific region of the alpha-pheromone receptor plays a selective role in the white cell pheromone response
Author(s):		Yi S; Sahni N; Pujol C; Daniels KJ; Srikantha T; Ma N; Soll DR;
Address:		"Department of Biology, The University of Iowa, Iowa City, IA 52242, USA"
Journal Title:		Mol Microbiol
Year:		2009
Volume:		20081218
Issue:		4
Page Number:		925 - 947
DOI:		10.1111/j.1365-2958.2008.06575.x
ISSN/ISBN:		1365-2958 (Electronic) 0950-382X (Linking)
Abstract:		"Candida albicans strains homozygous at the mating type locus can switch from white to opaque, and must do so to mate. Opaque cells then secrete mating pheromones that stimulate opaque cells of opposite mating type to undergo mating. These same pheromones stimulate mating-incompetent white cells to become cohesive and adhesive, and enhance white cell biofilm development, a pathogenic trait. Stimulation is mediated through the same receptor, G protein complex and mitogen-activated protein kinase pathway. Here we present evidence that a C. albicans-specific 55-amino-acid region of the first intracellular loop, IC1, of the alpha-pheromone receptor Ste2p, is required for the alpha-pheromone response of white cells, but not that of opaque cells. This represents a unique regulatory configuration in which activation of a common pathway by the same ligand, the same receptor and the same signal transduction pathway is dependent on a unique region of an intracellular loop of the common receptor in one of the two responding phenotypes"
Keywords:		"Amino Acid Sequence Biofilms Candida albicans/genetics/*physiology Fungal Proteins/genetics/*metabolism Gene Expression Regulation, Fungal *Genes, Mating Type, Fungal Mitogen-Activated Protein Kinases/metabolism Molecular Sequence Data Pheromones/*metabol;"
Notes:		"MedlineYi, Song Sahni, Nidhi Pujol, Claude Daniels, Karla J Srikantha, Thyagarajan Ma, Ning Soll, David R eng AI2392/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2009/01/28 Mol Microbiol. 2009 Feb; 71(4):925-47. doi: 10.1111/j.1365-2958.2008.06575.x. Epub 2008 Dec 18"