« Previous AbstractDerivatization gas chromatography negative chemical ionization mass spectrometry for the analysis of trace organic pollutants and their metabolites in human biological samples    Next Abstract"Functional characterization of a novel gene, Hc-dhs-28 and its role in protecting the host after Haemonchus contortus infection through regulation of diapause formation" »

Ecotoxicol Environ Saf

Title:		The exposure risk of typical VOCs to the human beings via inhalation based on the respiratory deposition rates by proton transfer reaction-time of flight-mass spectrometer
Author(s):		Yang Y; Luo H; Liu R; Li G; Yu Y; An T;
Address:		"Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangzhou Key Laboratory Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China. Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangzhou Key Laboratory Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address: ligy1999@gdut.edu.cn. Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangzhou Key Laboratory Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address: yuyingxin@gdut.edu.cn"
Journal Title:		Ecotoxicol Environ Saf
Year:		2020
Volume:		20200420
Issue:
Page Number:		110615 -
DOI:		10.1016/j.ecoenv.2020.110615
ISSN/ISBN:		1090-2414 (Electronic) 0147-6513 (Linking)
Abstract:		"The respiratory deposition rates are the important analytical parameters for human health risk assessment related to the environmental volatile organic compounds (VOCs). In present study, the deposition rates from the linear regressions of CH(2)O, CH(5)N, C(2)H(6)O, C(2)H(4)O(2), C(3)H(8)O, C(6)H(6), C(7)H(8), C(8)H(8), and C(8)H(10) of 120 healthy volunteers were obtained with significantly different from the respective calculated deposition rates. The CH(2)O (formaldehyde) has the highest deposition rate, indicating the highest associated exposure risk of CH(2)O if the persons are exposed to the same concentrations of these VOCs through inhalation. In order to explore the effects of the breathing models and sampling time on the deposition rates of VOCs, volunteers were first asked to breathe successively with nasal-in-nasal-out, oral-in-nasal-out, and oral-in-oral-out breathing models before and after three meals for three days. Sampling time variation has no effect on the deposition rates of selected VOCs, while the deposition rates of C(2)H(4)O(2), C(3)H(8)O, C(6)H(6), C(7)H(8) and C(8)H(10) by nasal-in-nasal-out were significantly different from oral-in-oral-out and nasal-in-oral-out models. Among all the breathing models, nasal-in-oral-out comprises the entire respiratory system. In order to further validate the results, the deposition rates of the selected VOCs were calculated in 120 healthy volunteers using nasal-in-oral-out breathing model for unlimited time after the conventional lung function examination. Difference in gender and body mass index had no effect on the deposition rates of VOCs, while the age affects the deposition rates of CH(2)O, CH(5)N and C(2)H(4)O(2). Positive correlation analysis between lung function factors and deposition rates revealed that the individuals with larger lung function factors are more susceptible to deposit the VOCs. Overall, the main conclusion can be drawn that the respiratory deposition rates were influenced by the physiological factors. Therefore, the major objective for future research is to accurately calculate the deposition rates of environmental VOCs for health-risk assessment"
Keywords:		Adult Air Pollutants/*analysis/toxicity Female Humans *Inhalation Exposure Male Mass Spectrometry Protons Respiration Respiratory Rate Risk Assessment Volatile Organic Compounds/*analysis/toxicity Conventional lung function Inhalation exposure Ptr-tof-ms;
Notes:		"MedlineYang, Yi Luo, Hao Liu, Ranran Li, Guiying Yu, Yingxin An, Taicheng eng Netherlands 2020/04/24 Ecotoxicol Environ Saf. 2020 Jul 1; 197:110615. doi: 10.1016/j.ecoenv.2020.110615. Epub 2020 Apr 20"