| Title: | Expansion of vomeronasal receptor genes (OlfC) in the evolution of fright reaction in Ostariophysan fishes |
| Author(s): | Yang L; Jiang H; Wang Y; Lei Y; Chen J; Sun N; Lv W; Wang C; Near TJ; He S; |
| Address: | "1The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072 People's Republic of China. 2University of Chinese Academy of Sciences, 100049 Beijing, People's Republic of China. 3School of Life Sciences, Jianghan University, 430056 Wuhan, People's Republic of China. 4Department of Ecology and Evolutionary Biology and Peabody Museum of Natural History, Yale University, New Haven, CT 06520 USA. 5Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, 650223 Kunming, People's Republic of China" |
| DOI: | 10.1038/s42003-019-0479-2 |
| ISSN/ISBN: | 2399-3642 (Electronic) 2399-3642 (Linking) |
| Abstract: | "Ostariophysans are the most diverse group of freshwater fishes and feature a pheromone-elicited fright reaction. However, the genetic basis of fright reaction is unclear. Here, we compared vomeronasal type 2 receptor-like (OlfC) genes from fishes having and lacking fright reaction, to provide insight into evolution of pheromonal olfaction in fishes. We found OlfC genes expanded remarkably in ostariophysans having fright reaction compared with fishes lacking fright reaction. Phylogenetic analysis indicates OlfC subfamily 9 expanded specifically in ostariophysans having fright reaction. Principle component and phylogenetic logistic regression analysis partitioned fishes by ecotype (having or lacking fright reaction) and identified OlfC subfamily 9 as being an important factor for fright reaction. Expression levels of expanded OlfC subfamily genes after fright reaction in zebrafish changed more than did genes that had not expanded. Furthermore, evidence of positive selection was found in the expanded OlfC proteins in ostariophysan fishes having fright reaction. These results provide new insight into the genetic basis of fright reaction in ostariophysan fish and will enable future research into the mechanism of action of OlfC proteins" |
| Keywords: | "Animals *Behavior, Animal Defense Mechanisms Fishes/genetics/*physiology Logistic Models Phylogeny Receptors, Odorant/*genetics Evolution Genetics;" |
| Notes: | "MedlineYang, Liandong Jiang, Haifeng Wang, Ying Lei, Yi Chen, Juan Sun, Ning Lv, Wenqi Wang, Cheng Near, Thomas J He, Shunping eng Research Support, Non-U.S. Gov't England 2019/07/03 Commun Biol. 2019 Jun 21; 2:235. doi: 10.1038/s42003-019-0479-2. eCollection 2019" |
