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Int J Nanomedicine

Title:		Breath volatolomics for diagnosing chronic rhinosinusitis
Author(s):		Broza YY; Braverman I; Haick H;
Address:		"The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa, Israel, hhossam@technion.ac.il. The Otolaryngology - Head & Neck Surgery Unit, The Hillel Yaffe Medical Center, The Technion Faculty of Medicine, Hadera, Israel"
Journal Title:		Int J Nanomedicine
Year:		2018
Volume:		20180814
Issue:
Page Number:		4661 - 4670
DOI:		10.2147/IJN.S171488
ISSN/ISBN:		1178-2013 (Electronic) 1176-9114 (Print) 1176-9114 (Linking)
Abstract:		"PURPOSE: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases treated by primary care physicians. It is increasingly recognized that CRS and nasal polyposis (NP) comprise several disease processes with diverse causes. Hence, subgroups of sinusitis need to be differentiated so that patients can be screened appropriately and personalized medical treatment provided. PATIENTS AND METHODS: To address this need, we use a cross-reactive nanoarray based on either molecularly modified gold nanoparticles or molecularly modified single-walled carbon nanotubes, combined with pattern recognition for analyzing breath samples. Breath samples were collected from three groups of volunteers (total 71) at the Hillel Yaffe Medical Center: CRS, NP, and control. RESULTS: Nanoarray results discriminated between patients with sinusitis and the control group with 87% sensitivity, 83% specificity, and 85% accuracy. The system also discriminated well between the subpopulations: 1) CRS vs control (76% sensitivity, 90% specificity); 2) CRS vs NP (82% sensitivity, 71% specificity); and 3) NP vs control (71% sensitivity, 90% specificity). CONCLUSION: This preliminary study shows that a nanoarray-based breath test for screening population for sinusitis-related conditions is feasible"
Keywords:		"Adult Aged Breath Tests/*methods Chronic Disease Discriminant Analysis Female Gold/chemistry Humans Male *Metabolomics Metal Nanoparticles/chemistry Middle Aged Nanotechnology Nanotubes, Carbon/chemistry Rhinitis/*diagnosis Sinusitis/*diagnosis Volatile O;"
Notes:		"MedlineBroza, Yoav Y Braverman, Itzhak Haick, Hossam eng New Zealand 2018/08/28 Int J Nanomedicine. 2018 Aug 14; 13:4661-4670. doi: 10.2147/IJN.S171488. eCollection 2018"