| Title: | Combined volatolomics for monitoring of human body chemistry |
| Author(s): | Broza YY; Zuri L; Haick H; |
| Address: | "The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 3200003, Israel" |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanomaterial-based sensors array, we demonstrate that simultaneous VOC detection from breath and skin would provide complementary, non-correlated information of the body's volatile metabolites profile. Eventually with further wide population validation studies, such a methodology could provide more accurate monitoring of pathological changes compared to the information provided by a single body fluid. The qualitative and quantitative methods presented here offers a variety of options for novel mapping of the metabolic properties of complex organisms, including humans" |
| Keywords: | Adult Biochemical Phenomena Breath Tests Female Gas Chromatography-Mass Spectrometry Human Body Humans Male Metabolomics Principal Component Analysis Skin/*chemistry Volatile Organic Compounds/*analysis; |
| Notes: | "MedlineBroza, Yoav Y Zuri, Liat Haick, Hossam eng Research Support, Non-U.S. Gov't England 2014/04/10 Sci Rep. 2014 Apr 9; 4:4611. doi: 10.1038/srep04611" |
