| Title: | "Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase" |
| Author(s): | Atoui A; Bao D; Kaur N; Grayburn WS; Calvo AM; |
| Address: | "Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA" |
| ISSN/ISBN: | 1098-5336 (Electronic) 0099-2240 (Print) 0099-2240 (Linking) |
| Abstract: | "The Aspergillus nidulans putative mitogen-activated protein kinase encoded by mpkB has a role in natural product biosynthesis. An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels. The mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA, which has been found to regulate secondary metabolism gene clusters" |
| Keywords: | "Aspergillus nidulans/*metabolism Biological Products/*biosynthesis Gene Deletion Gene Expression Profiling Gene Expression Regulation, Fungal Indoles/metabolism Mitogen-Activated Protein Kinases/genetics/*metabolism Penicillins/biosynthesis Pheromones/*me;" |
| Notes: | "MedlineAtoui, Ali Bao, Dapeng Kaur, Navgeet Grayburn, W Scott Calvo, Ana M eng Research Support, Non-U.S. Gov't 2008/04/02 Appl Environ Microbiol. 2008 Jun; 74(11):3596-600. doi: 10.1128/AEM.02842-07. Epub 2008 Mar 31" |
