| Title: | A Novel Urine Test Biosensor Platform for Early Lung Cancer Detection |
| Author(s): | Wiesel O; Sung SW; Katz A; Leibowitz R; Bar J; Kamer I; Berger I; Nir-Ziv I; Mark Danieli M; |
| Address: | "Division of Thoracic and Esophageal Surgery the Cardiovascular Center, Tzafon Medical Center, Affiliated to Azrieli Faculty of Medicine, Bar-Ilan University, Poriya 1520800, Israel. Department of Thoracic and Cardiovascular Surgery, Ewha Womens University Seoul Hospital, 260 Gonghang-daero, Gangseo-gu, Seoul 07804, Republic of Korea. Head of Thoracic Surgery, Rambam Health Care Campus, P.O. Box 9602, Haifa 3109601, Israel. Oncology institute, Shamir Medical Center, Zerifin 703001, Israel. Institute of Oncology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel. Early OM, 4 Meir Ariel St., Natanya 4253063, Israel" |
| ISSN/ISBN: | 2079-6374 (Electronic) 2079-6374 (Linking) |
| Abstract: | "Lung cancer is the leading cause of cancer-related mortality worldwide. Early detection is essential to achieving a better outcome and prognosis. Volatile organic compounds (VOCs) reflect alterations in the pathophysiology and body metabolism processes, as shown in various types of cancers. The biosensor platform (BSP) urine test uses animals' unique, proficient, and accurate ability to scent lung cancer VOCs. The BSP is a testing platform for the binary (negative/positive) recognition of the signature VOCs of lung cancer by trained and qualified Long-Evans rats as biosensors (BSs). The results of the current double-blind study show high accuracy in lung cancer VOC recognition, with 93% sensitivity and 91% specificity. The BSP test is safe, rapid, objective and can be performed repetitively, enabling periodic cancer monitoring as well as an aid to existing diagnostic methods. The future implementation of such urine tests as routine screening and monitoring tools has the potential to significantly increase detection rate as well as curability rates with lower healthcare expenditure. This paper offers a first instructive clinical platform utilizing VOC's in urine for detection of lung cancer using the innovative BSP to deal with the pressing need for an early lung cancer detection test tool" |
| Keywords: | "Animals Rats *Biosensing Techniques/methods Early Detection of Cancer/methods *Lung Neoplasms/diagnosis Rats, Long-Evans *Volatile Organic Compounds/urine Double-Blind Method biomarkers biosensors early detection early diagnosis lung cancer screening vola;" |
| Notes: | "MedlineWiesel, Ory Sung, Sook-Whan Katz, Amit Leibowitz, Raya Bar, Jair Kamer, Iris Berger, Itay Nir-Ziv, Inbal Mark Danieli, Michal eng Switzerland 2023/06/27 Biosensors (Basel). 2023 Jun 6; 13(6):627. doi: 10.3390/bios13060627" |
