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Mol Gen Genet

Title:		Expression of MF alpha 1 in MATa cells supersensitive to alpha-factor leads to self-arrest
Author(s):		Whiteway M; Hougan L; Thomas DY;
Address:		"Genetic Engineering Section, NRC Biotechnology Research Institute, Montreal, Que., Canada"
Journal Title:		Mol Gen Genet
Year:		1988
Volume:		214
Issue:		1
Page Number:		85 - 88
DOI:		10.1007/BF00340184
ISSN/ISBN:		0026-8925 (Print) 0026-8925 (Linking)
Abstract:		"MATa cells of Saccharomyces cerevisiae defective in both the SST1 and SST2 gene products exhibit self-arrest when they express the MF alpha 1 gene under the control of the GAL1 promoter. This response to endogenously produced pheromone can be alleviated by mutations which prevent the production of, or response to, alpha-factor. Suppressors of the self-arrest phenotype include a class of mutants which remain responsive to low levels of pheromone, but are resistant to high levels of alpha-factor. One of these mutants has been mapped to chromosome X, 31 cM distal to SUP4, and defines a new locus designated STE18"
Keywords:		"Crosses, Genetic Diploidy *Gene Expression Regulation *Genes, Fungal Mating Factor Mutation Peptide Biosynthesis Peptides/*genetics/physiology Promoter Regions, Genetic Saccharomyces cerevisiae/*genetics/growth & development Transformation, Genetic;"
Notes:		"MedlineWhiteway, M Hougan, L Thomas, D Y eng Germany 1988/09/01 Mol Gen Genet. 1988 Sep; 214(1):85-8. doi: 10.1007/BF00340184"