« Previous AbstractAnalysis of volatiles induced by oviposition of elm leaf beetle Xanthogaleruca luteola on Ulmus minor    Next AbstractAdvanced scripting for the automated profiling of two-dimensional gas chromatography-time-of-flight mass spectrometry data from combustion aerosol »

J Comp Neurol

Title:		Fenvalerate treatment affects development of olfactory glomeruli in Manduca sexta
Author(s):		Wegerhoff R; Rossler W; Higgins M; Oland LA; Tolbert LP;
Address:		"Institute of Biochemistry, University of Kiel, D-24098 Kiel, Germany. rwegerhoff@netscape.net"
Journal Title:		J Comp Neurol
Year:		2001
Volume:		430
Issue:		4
Page Number:		533 - 541
DOI:		10.1002/1096-9861(20010219)430:4<533::aid-cne1048>3.0.co;2-d
ISSN/ISBN:		0021-9967 (Print) 0021-9967 (Linking)
Abstract:		"Low doses of fenvalerate, a widely used type-II pyrethroid insecticide, have been shown previously to produce abnormal olfactory centers in the brain and abnormal olfactory-mediated behavior in beetles (Wegerhoff et al. [1998] Neuroreport 9:3241-3245). Here, we use the experimental advantages of the moth Manduca sexta to explore the cellular changes that lead to these abnormalities. Our results indicate that treatment with fenvalerate may affect multiple aspects of the development of the primary olfactory centers, the antennal lobes, in Manduca, including ingrowth of olfactory receptor axons, axon fasciculation, and targeting within the antennal lobe, and intercellular signaling between the receptor axons and the glial cells that ordinarily surround and stabilize the developing olfactory glomeruli"
Keywords:		"Animals Antibodies Female Ganglia, Invertebrate/chemistry/drug effects/growth & development Insect Proteins/analysis/immunology Insecticides/*pharmacology Male Manduca/*drug effects Metamorphosis, Biological/drug effects Nitriles Olfactory Receptor Neuron;"
Notes:		"MedlineWegerhoff, R Rossler, W Higgins, M Oland, L A Tolbert, L P eng NS20040/NS/NINDS NIH HHS/ NS28495/NS/NINDS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 2001/02/13 J Comp Neurol. 2001 Feb 19; 430(4):533-41. doi: 10.1002/1096-9861(20010219)430:4<533::aid-cne1048>3.0.co; 2-d"