| Title: | Neuronal control of maternal provisioning in response to social cues |
| Author(s): | Wasson JA; Harris G; Keppler-Ross S; Brock TJ; Dar AR; Butcher RA; Fischer SEJ; Kagias K; Clardy J; Zhang Y; Mango SE; |
| Address: | "Biozentrum, University of Basel, Basel, Switzerland. Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA. Department of Biology, California State University Channel Islands, Camarillo, CA, USA. InVivo Biosystems, Eugene, OR, USA. Department of Chemistry, University of Florida, Gainesville, FL, USA. Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Cambridge, MA, USA. Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA. susan.mango@unibas.ch yzhang@oeb.harvard.edu. Biozentrum, University of Basel, Basel, Switzerland. susan.mango@unibas.ch yzhang@oeb.harvard.edu" |
| ISSN/ISBN: | 2375-2548 (Electronic) 2375-2548 (Linking) |
| Abstract: | "Mothers contribute cytoplasmic components to their progeny in a process called maternal provisioning. Provisioning is influenced by the parental environment, but the molecular pathways that transmit environmental cues between generations are not well understood. Here, we show that, in Caenorhabditis elegans, social cues modulate maternal provisioning to regulate gene silencing in offspring. Intergenerational signal transmission depends on a pheromone-sensing neuron and neuronal FMRFamide (Phe-Met-Arg-Phe)-like peptides. Parental FMRFamide-like peptide signaling dampens oxidative stress resistance and promotes the deposition of mRNAs for translational components in progeny, which, in turn, reduces gene silencing. This study identifies a previously unknown pathway for intergenerational communication that links neuronal responses to maternal provisioning. We suggest that loss of social cues in the parental environment represents an adverse environment that stimulates stress responses across generations" |
| Notes: | "PubMed-not-MEDLINEWasson, Jadiel A Harris, Gareth Keppler-Ross, Sabine Brock, Trisha J Dar, Abdul R Butcher, Rebecca A Fischer, Sylvia E J Kagias, Konstantinos Clardy, Jon Zhang, Yun Mango, Susan E eng P40 OD010440/OD/NIH HHS/ R01 AT009874/AT/NCCIH NIH HHS/ R01 GM118775/GM/NIGMS NIH HHS/ R37 GM056264/GM/NIGMS NIH HHS/ 2021/08/22 Sci Adv. 2021 Aug 20; 7(34):eabf8782. doi: 10.1126/sciadv.abf8782. Print 2021 Aug" |
