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Chemosphere

Title:		Associations between the compositional patterns of blood volatile organic compounds and chronic respiratory diseases and ages at onset in NHANES 2003-2012
Author(s):		Wang Y; Han X; Li J; Zhang L; Liu Y; Jin R; Chen L; Chu X;
Address:		"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, 150081, China. Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin 150081, China. Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, 150081, China; Heilongjiang Academy of Medical Sciences, Harbin, 150081, China. Electronic address: cx831128@163.com"
Journal Title:		Chemosphere
Year:		2023
Volume:		20230315
Issue:
Page Number:		138425 -
DOI:		10.1016/j.chemosphere.2023.138425
ISSN/ISBN:		1879-1298 (Electronic) 0045-6535 (Linking)
Abstract:		"BACKGROUND: and Purpose Volatile organic compounds (VOCs) pose a serious respiratory hazard. This study evaluated the relationship between the compositional patterns of blood VOCs and the risk and age at onset of chronic respiratory diseases (CRDs), including asthma, emphysema and chronic bronchitis, with the objective of preventing or delaying CRDs. METHODS: Participants from five cycles of the NHANES survey were included. Blood VOCs were clustered using k-means clustering. Differences in VOCs and age at onset between multiple groups were compared with the Kruskal?ªªWallis test. Logistic regression and a generalized linear model were applied to examine the associations between different compositional patterns of blood VOCs and risk and age at onset of CRDs. RESULTS: 12,386 participants were enrolled in this study. Three VOC compositional patterns were identified after clustering nine species of blood VOCs. The concentration of VOCs in pattern 2 was relatively low and stable. The concentrations of benzene, ethylbenzene, o-xylene, styrene, toluene and m-p-xylene in pattern 3 and the concentrations of 1,4-dichlorobenzene and MTBE in pattern 1 were significantly higher than those in pattern 2. After adjustment for covariates, the participants with VOC pattern 3 had an increased risk of asthma (OR = 1.23, 95% CI: 1.02, 1.49), emphysema (OR = 3.37, 95% CI: 2.24, 5.06) and chronic bronchitis (OR = 1.79, 95% CI: 1.30, 2.45). Meanwhile, VOC pattern 3 was negatively correlated with the age at onset of asthma (beta = -5.61, 95% CI: 9.69, -1.52) and chronic bronchitis (beta = -9.17, 95% CI: 13.96, -4.39). VOC pattern 1 was not associated with either risk or age at onset of the three CRDs after adjustment. CONCLUSIONS: Changing the compositional pattern of blood VOCs by reducing certain species of VOCs may be a new strategy to lengthen the ages at onset of CRDs and effectively prevent them"
Keywords:		"Humans *Volatile Organic Compounds/analysis *Air Pollutants/analysis Nutrition Surveys *Bronchitis, Chronic/epidemiology Age of Onset *Asthma/epidemiology *Respiration Disorders *Emphysema Environmental Monitoring Age at onset Chronic respiratory diseases;"
Notes:		"MedlineWang, Yuanyuan Han, Xinhao Li, Jingkun Zhang, Liuchao Liu, Yu Jin, Ruifang Chen, Liang Chu, Xia eng England 2023/03/18 Chemosphere. 2023 Jun; 327:138425. doi: 10.1016/j.chemosphere.2023.138425. Epub 2023 Mar 15"