| Title: | Exposure to volatile organic compounds is a risk factor for diabetes: A cross-sectional study |
| Author(s): | Wang X; He W; Wu X; Song X; Yang X; Zhang G; Niu P; Chen T; |
| Address: | "Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, 100069, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Department of Endocrinology, Fu Xing Hospital, Capital Medical University, 100038, Beijing, China. Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, 100069, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address: niupiye@ccmu.edu.cn. Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, 100069, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address: chentian@ccmu.edu.cn" |
| DOI: | 10.1016/j.chemosphere.2023.139424 |
| ISSN/ISBN: | 1879-1298 (Electronic) 0045-6535 (Linking) |
| Abstract: | "Currently, more studies showed that environmental chemicals were associated with the development of diabetes. However, the effect of volatile organic compounds (VOCs) on diabetes remained uncertain and needed to be studied. This cross-sectional study examined whether exposure to low levels of VOCs was associated with diabetes, insulin resistance (TyG index) and glucose-related indicators (FPG,HbA1c, insulin) in the general population by using the NHANES dataset (2013-2014 and 2015-2016). We analyzed the association between urinary VOC metabolism (mVOCs) and these indicators in 1409 adults by multiple linear regression models or logistic regression models, further Bayesian kernel machine regression (BKMR) models were performed for mixture exposure analysis. The results showed positive associations between multiple mVOCs and diabetes, TyG index, FPG, HbA1c and insulin, respectively. Among them, HPMMA concentration in urine was significantly positively correlated with diabetes and related indicators (TyG index, FPG and HbA1c), and the concentration of CEMA was significantly positively correlated with insulin. The positive association of mVOCs with diabetes and its related indicators was more significant in the female group and in the 40-59 years group. Thus, our study suggested that exposure to VOCs affected insulin resistance and glucose homeostasis, further affecting diabetes levels, which had important public health implications" |
| Keywords: | Adult Humans Female *Volatile Organic Compounds/toxicity *Insulin Resistance Cross-Sectional Studies Glycated Hemoglobin Blood Glucose/analysis Nutrition Surveys Bayes Theorem Risk Factors Insulin Glucose Triglycerides Biomarkers/analysis *Diabetes Mellit; |
| Notes: | "MedlineWang, Xueting He, Weifeng Wu, Xiaojuan Song, Xin Yang, Xin Zhang, Gaoman Niu, Piye Chen, Tian eng England 2023/07/08 Chemosphere. 2023 Oct; 338:139424. doi: 10.1016/j.chemosphere.2023.139424. Epub 2023 Jul 5" |
