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Science

Title:		"Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating"
Author(s):		Wang G; Vega-Rodriguez J; Diabate A; Liu J; Cui C; Nignan C; Dong L; Li F; Ouedrago CO; Bandaogo AM; Sawadogo PS; Maiga H; Alves ES; Pascini TV; Wang S; Jacobs-Lorena M;
Address:		"CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences (CAS), Shanghai, China. CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, China. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA. Institut de Recherche en Science de la Sante (IRSS), Bobo-Dioulasso, Burkina Faso. School of Life Science and Technology, ShanghaiTech University, Shanghai, China. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences (CAS), Shanghai, China. sbwang@cemps.ac.cn ljacob13@jhu.edu. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA. sbwang@cemps.ac.cn ljacob13@jhu.edu"
Journal Title:		Science
Year:		2021
Volume:		371
Issue:		6527
Page Number:		411 - 415
DOI:		10.1126/science.abd4359
ISSN/ISBN:		1095-9203 (Electronic) 0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Anopheles mating is initiated by the swarming of males at dusk followed by females flying into the swarm. Here, we show that mosquito swarming and mating are coordinately guided by clock genes, light, and temperature. Transcriptome analysis shows up-regulation of the clock genes period (per) and timeless (tim) in the head of field-caught swarming Anopheles coluzzii males. Knockdown of per and tim expression affects Anopheles gambiae s.s. and Anopheles stephensi male mating in the laboratory, and it reduces male An. coluzzii swarming and mating under semifield conditions. Light and temperature affect mosquito mating, possibly by modulating per and/or tim expression. Moreover, the desaturase gene desat1 is up-regulated and rhythmically expressed in the heads of swarming males and regulates the production of cuticular hydrocarbons, including heptacosane, which stimulates mating activity"
Keywords:		"Animals Anopheles/genetics/*physiology CLOCK Proteins/genetics/*physiology Fatty Acid Desaturases/genetics/metabolism *Flight, Animal *Gene-Environment Interaction Light Male Period Circadian Proteins/genetics/*physiology Pheromones/*biosynthesis *Sexual;"
Notes:		"MedlineWang, Guandong Vega-Rodriguez, Joel Diabate, Abdoulaye Liu, Jingnan Cui, Chunlai Nignan, Charles Dong, Ling Li, Fang Ouedrago, Cheick Oumar Bandaogo, Abdoul Malik Sawadogo, Peguedwinde Simon Maiga, Hamidou Alves E Silva, Thiago Luiz Pascini, Tales Vicari Wang, Sibao Jacobs-Lorena, Marcelo eng R01 AI031478/AI/NIAID NIH HHS/ R01 AI051366/AI/NIAID NIH HHS/ R01 AI127405/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't 2021/01/23 Science. 2021 Jan 22; 371(6527):411-415. doi: 10.1126/science.abd4359"