| Title: | Membrane interactions of ionic liquids and imidazolium salts |
| Author(s): | Wang D; Galla HJ; Drucker P; |
| Address: | "Institute of Biochemistry, Westfalische Wilhelms-University Munster, Wilhelm-Klemm-Strasse 2, D-48149, Munster, Germany. Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstrasse 2, 3000, Bern 9, Switzerland. patrick.druecker@ana.unibe.ch" |
| DOI: | 10.1007/s12551-017-0388-x |
| ISSN/ISBN: | 1867-2450 (Print) 1867-2469 (Electronic) 1867-2450 (Linking) |
| Abstract: | "Room-temperature ionic liquids (RTILs) have attracted considerable attention in recent years due to their versatile properties such as negligible volatility, inflammability, high extractive selectivity and thermal stability. In general, RTILs are organic salts with a melting point below ~100 degrees C determined by the asymmetry of at least one of their ions. Due to their amphiphilic character, strong interactions with biological materials can be expected. However, rising attention has appeared towards their similarity and interaction with biomolecules. By employing structural modifications, the biochemical properties of RTILs can be designed to mimic lipid structures and to tune their hydrophobicity towards a lipophilic behavior. This is evident for the interaction with lipid-membranes where some of these compounds present membrane-disturbing effects or cellular toxicity. Moreover, they can form micelles or lipid-like bilayer structures by themselves. Both aspects, cellular effects and membrane-forming capacities, of a novel class of lipophilic imidazolium salts will be discussed" |
| Keywords: | Bilayer Biomembrane Imidazolium salt Ionic liquid Micelle Vesicle; |
| Notes: | "PubMed-not-MEDLINEWang, Da Galla, Hans-Joachim Drucker, Patrick eng Review Germany 2018/01/06 Biophys Rev. 2018 Jun; 10(3):735-746. doi: 10.1007/s12551-017-0388-x. Epub 2018 Jan 4" |
