| Title: | Models of toxicity of diacetyl and alternative diones |
| Address: | "Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA. Electronic address: david.brass@duke.edu. Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA" |
| DOI: | 10.1016/j.tox.2017.02.011 |
| ISSN/ISBN: | 1879-3185 (Electronic) 0300-483X (Print) 0300-483X (Linking) |
| Abstract: | "Diacetyl (DA; 2,3-butanedione), with the chemical formula (CH(3)CO)(2) is a volatile organic compound with a deep yellow color and a strong buttery flavor and aroma. These properties have made DA a particularly useful and common food flavoring ingredient. However, because of this increased occupational use, workers can be exposed to high vapor concentrations in the workplace. Despite being listed by the USFDA to be 'generally regarded as safe' (GRAS), multiple lines of evidence suggest that exposure to high concentrations of DA vapor causes long-term impairments in lung function with lung function testing indicating evidence of either restrictive or obstructive airway narrowing in affected individuals. A growing number of pre-clinical studies have now addressed the short and long-term toxicity associated with DA exposure providing further insight into the toxicity of DA and related diones. This review summarizes these observations" |
| Keywords: | Animals Diacetyl/chemistry/*toxicity Flavoring Agents/*toxicity Humans Inhalation Exposure/adverse effects Lung Diseases/chemically induced/epidemiology Occupational Diseases/chemically induced/epidemiology Occupational Exposure/*adverse effects Respirato; |
| Notes: | "MedlineBrass, David M Palmer, Scott M eng R21 OH010490/OH/NIOSH CDC HHS/ Review Ireland 2017/02/25 Toxicology. 2017 Aug 1; 388:15-20. doi: 10.1016/j.tox.2017.02.011. Epub 2017 Feb 21" |
