| Title: | "Exhaled Breath Profiles Before, During and After Exacerbation of COPD: A Prospective Follow-Up Study" |
| Author(s): | van Velzen P; Brinkman P; Knobel HH; van den Berg JWK; Jonkers RE; Loijmans RJ; Prins JM; Sterk PJ; |
| Address: | "Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands. Eurofins Materials Science Netherlands BV, Eindhoven, Netherlands. Department of Respiratory Medicine, Isala Clinics, Zwolle, Netherlands. Department of General Practice, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands. Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands" |
| DOI: | 10.1080/15412555.2019.1669550 |
| ISSN/ISBN: | 1541-2563 (Electronic) 1541-2563 (Linking) |
| Abstract: | "Many patients with chronic obstructive lung disease (COPD) experience exacerbations. The diagnosis of an exacerbation is solely based on symptoms. We hypothesized that exhaled breath profiles, measured by Gas Chromatography-Mass Spectrometry (GC-MS) or electronic nose (eNose), are different between stable disease and exacerbations and may have the potential to serve as biomarkers for COPD exacerbations. In this prospective follow-up study, breath samples were taken during stable COPD, during a subsequent exacerbation and after recovery. Samples were analyzed by GC-MS and eNose. CCQ symptom scores were associated with univariate outcomes of GC-MS and eNose using analysis of covariance (ANCOVA). After multivariate modeling by Principal Component Analysis (PCA), paired student t-tests were performed. Sixty-eight patients were included, 31 had an exacerbation and 16 patients had breath sampled at all three time points. Significant differences were found in breathprints taken during exacerbation as compared to baseline and recovery for both GC-MS and eNose. Breath profiles obtained by GC-MS as well as by eNose showed a correct classification of 71% (10/14) for baseline vs exacerbation and of 78% (11/14) for exacerbation vs recovery. These results provide proof of principle that exhaled breath can serve as a noninvasive biomarker for the diagnosis of COPD exacerbations" |
| Keywords: | "Aged Aged, 80 and over Biomarkers/metabolism Breath Tests Disease Progression Electronic Nose Exhalation Female Follow-Up Studies Gas Chromatography-Mass Spectrometry Humans Male Middle Aged Multivariate Analysis Principal Component Analysis Prospective S;" |
| Notes: | "Medlinevan Velzen, P Brinkman, P Knobel, H H van den Berg, J W K Jonkers, R E Loijmans, R J Prins, J M Sterk, P J eng Observational Study Research Support, Non-U.S. Gov't England 2019/10/08 COPD. 2019 Dec; 16(5-6):330-337. doi: 10.1080/15412555.2019.1669550. Epub 2019 Oct 7" |
