| Title: | Hyperbaric oxygen diving affects exhaled molecular profiles in men |
| Author(s): | van Ooij PJ; van Hulst RA; Kulik W; Brinkman P; Houtkooper A; Sterk PJ; |
| Address: | "Diving Medical Center, Royal Netherlands Navy, Den Helder, The Netherlands; Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: pjam.v.ooij.01@mindef.nl. Diving Medical Center, Royal Netherlands Navy, Den Helder, The Netherlands; Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Diving Medical Center, Royal Netherlands Navy, Den Helder, The Netherlands" |
| DOI: | 10.1016/j.resp.2014.03.009 |
| ISSN/ISBN: | 1878-1519 (Electronic) 1569-9048 (Linking) |
| Abstract: | "Exhaled breath contains volatile organic compounds (VOCs) that are associated with respiratory pathophysiology. We hypothesized that hyperbaric oxygen exposure (hyperoxia) generates a distinguishable VOC pattern. This study aimed to test this hypothesis in oxygen-breathing divers. VOCs in exhaled breath were measured in 10 male divers before and 4h after diving to 9msw (190kPa) for 1h. During the dive they breathed 100% oxygen or air in randomized order. VOCs were determined using two-dimensional gas chromatography with time-of-flight mass spectrometry. Compared to air dives, after oxygen dives there was a significant increase in five VOCs (predominately methyl alkanes). Furthermore, a strong, positive correlation was found between increments in 2,4-dimethyl-hexane and those of 4-ethyl-5-methyl-nonane. Although non-submerged hyperoxia studies on VOCs have been performed, the present study is the first to demonstrate changes in exhaled molecular profiles after submerged oxygen diving. The pathophysiological background might be attributed to either a lipid peroxidation-induced pathway, an inflammatory pathway, or to both" |
| Keywords: | Adult Air Blood Chemical Analysis Breath Tests/methods Cross-Over Studies Diving/*physiology Double-Blind Method Exhalation/*physiology Humans Hyperbaric Oxygenation/*methods Hyperoxia/*metabolism Male Malondialdehyde/blood Smoking/metabolism Volatile Org; |
| Notes: | "Medlinevan Ooij, P J A M van Hulst, R A Kulik, W Brinkman, P Houtkooper, A Sterk, P J eng Randomized Controlled Trial Netherlands 2014/04/08 Respir Physiol Neurobiol. 2014 Jul 1; 198:20-4. doi: 10.1016/j.resp.2014.03.009. Epub 2014 Apr 1" |
