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Eur Arch Otorhinolaryngol

Title:		Differentiating head and neck carcinoma from lung carcinoma with an electronic nose: a proof of concept study
Author(s):		van Hooren MR; Leunis N; Brandsma DS; Dingemans AC; Kremer B; Kross KW;
Address:		"Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. michel.hooren@mumc.nl. Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. Department of Pulmonology, Maastricht University Medical Center, Maastricht, The Netherlands"
Journal Title:		Eur Arch Otorhinolaryngol
Year:		2016
Volume:		20160416
Issue:		11
Page Number:		3897 - 3903
DOI:		10.1007/s00405-016-4038-x
ISSN/ISBN:		1434-4726 (Electronic) 0937-4477 (Print) 0937-4477 (Linking)
Abstract:		"Disease specific patterns of volatile organic compounds can be detected in exhaled breath using an electronic nose (e-nose). The aim of this study is to explore whether an e-nose can differentiate between head and neck, and lung carcinoma. Eighty-seven patients received an e-nose measurement before any oncologic treatment. We used PARAFAC/TUCKER3 tensor decomposition for data reduction and an artificial neural network for analysis to obtain binary results; either diagnosed as head and neck or lung carcinoma. Via a leave-one-out method, cross-validation of the data was performed. In differentiating head and neck from lung carcinoma patients, a diagnostic accuracy of 93 % was found. After cross-validation of the data, this resulted in a diagnostic accuracy of 85 %. There seems to be a potential for e-nose as a diagnostic tool in HNC and lung carcinoma. With a fair diagnostic accuracy, an e-nose can differentiate between the two tumor entities"
Keywords:		"Adult Aged Breath Tests Carcinoma/*diagnosis Diagnosis, Differential *Electronic Nose Exhalation Female Head and Neck Neoplasms/*diagnosis Humans Lung Neoplasms/*diagnosis Male Middle Aged Predictive Value of Tests Reproducibility of Results Volatile Orga;"
Notes:		"Medlinevan Hooren, Michel R A Leunis, Nicoline Brandsma, Dirk S Dingemans, Anne-Marie C Kremer, Bernd Kross, Kenneth W eng Germany 2016/04/17 Eur Arch Otorhinolaryngol. 2016 Nov; 273(11):3897-3903. doi: 10.1007/s00405-016-4038-x. Epub 2016 Apr 16"