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Cell Cycle

Title:		Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast
Author(s):		Van Drogen F; Dard N; Pelet S; Lee SS; Mishra R; Srejic N; Peter M;
Address:		"ETH Zurich, Institute for Biochemistry , Zurich, Switzerland. Ufr Smbh, University Sorbonne Paris Nord , Bobigny, France. Department of Fundamental Microbiology, University of Lausanne , Lausanne, Switzerland. ETH Zurich, Scientific Center for Optical and Electron Microscopy (ScopeM) , Zurich, Switzerland"
Journal Title:		Cell Cycle
Year:		2020
Volume:		20200618
Issue:		14
Page Number:		1707 - 1715
DOI:		10.1080/15384101.2020.1779469
ISSN/ISBN:		1551-4005 (Electronic) 1538-4101 (Print) 1551-4005 (Linking)
Abstract:		"Budding yeast, Saccharomyces cerevisiae, has been widely used as a model system to study cellular signaling in response to internal and external cues. Yeast was among the first organisms in which the architecture, feedback mechanisms and physiological responses of various MAP kinase signaling cascades were studied in detail. Although these MAP kinase pathways are activated by different signals and elicit diverse cellular responses, such as adaptation to stress and mating, they function as an interconnected signaling network, as they influence each other and, in some cases, even share components. Indeed, various stress signaling pathways interfere with pheromone signaling that triggers a distinct cellular differentiation program. However, the molecular mechanisms responsible for this crosstalk are still poorly understood. Here, we review the general topology of the yeast MAP kinase signaling network and highlight recent and new data revealing how conflicting intrinsic and extrinsic signals are interpreted to orchestrate appropriate cellular responses"
Keywords:		Mitogen-Activated Protein Kinases/*metabolism Pheromones/*metabolism Saccharomyces cerevisiae Proteins/*metabolism Saccharomycetales/*metabolism *Signal Transduction Time Factors Yeast MAP kinase signaling crosstalk;
Notes:		"MedlineVan Drogen, Frank Dard, Nicolas Pelet, Serge Lee, Sung Sik Mishra, Ranjan Srejic, Nevena Peter, Matthias eng Research Support, Non-U.S. Gov't Review 2020/06/20 Cell Cycle. 2020 Jul; 19(14):1707-1715. doi: 10.1080/15384101.2020.1779469. Epub 2020 Jun 18"