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J Chromatogr B Analyt Technol Biomed Life Sci

Title:		GC-MS analysis of breath odor compounds in liver patients
Author(s):		Van den Velde S; Nevens F; Van Hee P; van Steenberghe D; Quirynen M;
Address:		"Department of Periodontology, Faculty of Medicine, Catholic University of Leuven, Kapucijnenvoer 33, BE-3000 Leuven, Belgium"
Journal Title:		J Chromatogr B Analyt Technol Biomed Life Sci
Year:		2008
Volume:		20080917
Issue:		2
Page Number:		344 - 348
DOI:		10.1016/j.jchromb.2008.08.031
ISSN/ISBN:		1570-0232 (Print) 1570-0232 (Linking)
Abstract:		"BACKGROUND: Liver diseases can cause a sweet, musty aroma of the breath, called fetor hepaticus. Even in a stage of cirrhosis, the disease can be asymptomatic for many years. Breath analysis might be helpful to detect occult liver pathology. STUDY OBJECTIVE: This study examined whether specific breath odor compounds can be found in liver patients, suffering from cirrhosis, which might be useful for diagnosis. MATERIALS AND METHODS: Fifty-two liver patients and 50 healthy volunteers were enrolled. Alveolar air was analyzed by gas chromatography-mass spectrometry. Using discriminant analysis a model for liver disease was built. RESULTS: Dimethyl sulfide, acetone, 2-butanone and 2-pentanone were increased in breath of liver patients, while indole and dimethyl selenide were decreased. Sensitivity and specificity of the model were respectively 100% and 70%. CONCLUSIONS: Fetor hepaticus is caused by dimethyl sulfide and to a lower extent by ketones in alveolar air. Breath analysis by GC-MS makes it possible to discriminate patients with breath malodor related to hepatic pathologies"
Keywords:		Adult Breath Tests/*methods Case-Control Studies Diabetes Mellitus/metabolism Female Gas Chromatography-Mass Spectrometry/*methods Halitosis/*metabolism Humans Indoles/analysis Ketones/analysis Liver Cirrhosis/*metabolism Male Middle Aged Organoselenium C;
Notes:		"MedlineVan den Velde, Sandra Nevens, Frederik Van Hee, Paul van Steenberghe, Daniel Quirynen, Marc eng Research Support, Non-U.S. Gov't Netherlands 2008/10/22 J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 15; 875(2):344-8. doi: 10.1016/j.jchromb.2008.08.031. Epub 2008 Sep 17"