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Asian Pac J Trop Med

Title:		Medicinal plant products targeting quorum sensing for combating bacterial infections
Author(s):		Bouyahya A; Dakka N; Et-Touys A; Abrini J; Bakri Y;
Address:		"Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, And Genomic Center of Human Pathologies, Mohammed V University, Rabat, Morocco; Biology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek Essaadi University, Tetouan, Morocco. Electronic address: boyahyaa-90@hotmail.fr. Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, And Genomic Center of Human Pathologies, Mohammed V University, Rabat, Morocco. Biology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek Essaadi University, Tetouan, Morocco"
Journal Title:		Asian Pac J Trop Med
Year:		2017
Volume:		20170819
Issue:		8
Page Number:		729 - 743
DOI:		10.1016/j.apjtm.2017.07.021
ISSN/ISBN:		2352-4146 (Electronic) 1995-7645 (Linking)
Abstract:		"Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances"
Keywords:		Bacterial resistance Biofilms Natural compounds Quorum sensing;
Notes:		"PubMed-not-MEDLINEBouyahya, Abdelhakim Dakka, Nadia Et-Touys, Abdeslam Abrini, Jamal Bakri, Youssef eng Review India 2017/09/26 Asian Pac J Trop Med. 2017 Aug; 10(8):729-743. doi: 10.1016/j.apjtm.2017.07.021. Epub 2017 Aug 19"