| Title: | Investigation of the effect of gestational diabetes on fetal cardiac tissue in streptozotocin induced in rats |
| Author(s): | Turhan U; Yilmaz E; Gul M; Melekoglu R; Turkoz Y; Ozyalin F; Parlakpinar H; Simsek Y; |
| Address: | "MD, Department of Obstetrics and Gynecology, Faculty of Medicine, Health Science University, Kanuni Sultan Suleyman Education and Research Hospital, Istanbul, Turkey. Conception and design of the study. Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkey. Manuscript writing. Full Professor, Department of Histology and Embriyology, Faculty of Medicine, Inonu University, Malatya, Turkey. Histopathological examinations. Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkey. Acquisition of data. Full Professor, Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey. Technical procedures. MD, Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey. Statistical analysis. Full Professor, Department of Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey. Critical revision. Associate Professor, Private Clinic, Kirikkale, Turkey. Manuscript preparation" |
| DOI: | 10.1590/s0102-865020180040000002 |
| ISSN/ISBN: | 1678-2674 (Electronic) 0102-8650 (Linking) |
| Abstract: | "PURPOSE: To investigate the cause of congenital anomalies resulted from gestational diabetes on fetal cardiac tissue in experimental animal study model. METHODS: Totally 12 female Wistar albino rats were divided into two groups, each consisting of 6 rats. Streptozotocin (60 mg/kg) was administered intraperitoneally to the study group by dissolving in citrate solution. The rats with a blood glucose level of 200 mg/dL and above were considered to be diabetic rats. Total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress index (OSI) values were calculated in the cardiac tissues and maternal serum samples of the fetuses delivered by cesarean section after the mating process. The cardiac tissues were also subjected to histopathological examination. RESULTS: TOS and OSI values in fetal cardiac tissues of the diabetic rats were found to be significantly higher than that of the control group (p=0.026 and p=0.005). Histopathological examination revealed that the mitotic index was lower and the cell organization was found to be damaged in the fetuses of the study group rats. CONCLUSION: Increased levels of free oxygen radicals considered to be due to hyperglycemia may cause congenital anomalies, especially during organogenesis period, by disrupting cell homeostasis and adversely affecting mitosis" |
| Keywords: | "Animals Antioxidants/analysis Blood Glucose/analysis Diabetes Mellitus, Experimental/*complications *Diabetes, Gestational Female Heart/*embryology Heart Defects, Congenital/embryology/*etiology/*pathology Hyperglycemia/complications Microscopy Myocardium;" |
| Notes: | "MedlineTurhan, Ugur Yilmaz, Ercan Gul, Mehmet Melekoglu, Rauf Turkoz, Yusuf Ozyalin, Fatma Parlakpinar, Hakan Simsek, Yavuz eng Brazil 2018/05/17 Acta Cir Bras. 2018 Apr; 33(4):306-313. doi: 10.1590/s0102-865020180040000002" |
