| Title: | External ears for non-invasive and stable monitoring of volatile organic compounds in human blood |
| Author(s): | Toma K; Suzuki S; Arakawa T; Iwasaki Y; Mitsubayashi K; |
| Address: | "Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Tokyo, 113-8668, Japan. Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. m.bdi@tmd.ac.jp. Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. m.bdi@tmd.ac.jp" |
| DOI: | 10.1038/s41598-021-90146-1 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Volatile organic compounds (VOCs) released through skin (transcutaneous gas) has been increasing in importance for the continuous and real-time assessment of diseases or metabolisms. For stable monitoring of transcutaneous gas, finding a body part with little interference on the measurement is essential. In this study, we have investigated the possibility of external ears for stable and real-time measurement of ethanol vapour by developing a monitoring system that consisted with an over-ear gas collection cell and a biochemical gas sensor (bio-sniffer). The high sensitivity with the broad dynamic range (26 ppb-554 ppm), the high selectivity to ethanol, and the capability of the continuous measurement of the monitoring system uncovered three important characteristics of external ear-derived ethanol with alcohol intake for the first time: there is little interference from sweat glands to a sensor signal at the external ear; similar temporal change in ethanol concentration to that of breath with delayed peak time (avg. 13 min); relatively high concentration of ethanol relative to other parts of a body (external ear-derived ethanol:breath ethanol = 1:590). These features indicated the suitability of external ears for non-invasive monitoring of blood VOCs" |
| Keywords: | "Alcohol Dehydrogenase/chemistry Alcohol Drinking *Biosensing Techniques *Blood Gas Monitoring, Transcutaneous Breath Tests Ear, External/chemistry Enzymes, Immobilized/chemistry Ethanol/chemistry Gases/*blood Humans Volatile Organic Compounds/*blood;" |
| Notes: | "MedlineToma, Koji Suzuki, Shota Arakawa, Takahiro Iwasaki, Yasuhiko Mitsubayashi, Kohji eng Research Support, Non-U.S. Gov't England 2021/06/12 Sci Rep. 2021 Jun 10; 11(1):10415. doi: 10.1038/s41598-021-90146-1" |
