« Previous AbstractChemosensory regulation of development in C. elegans    Next AbstractThe Caenorhabditis chemoreceptor gene families »

Genetics

Title:		Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans
Author(s):		Thomas JH; Birnby DA; Vowels JJ;
Address:		"Department of Genetics, University of Washington, Seattle 98195"
Journal Title:		Genetics
Year:		1993
Volume:		134
Issue:		4
Page Number:		1105 - 1117
DOI:		10.1093/genetics/134.4.1105
ISSN/ISBN:		0016-6731 (Print) 0016-6731 (Linking)
Abstract:		"Dauer formation in Caenorhabditis elegans is induced by chemosensation of high levels of a constitutively secreted pheromone. Seven genes defined by mutations that confer a dauer-formation constitutive phenotype (Daf-c) can be congruently divided into two groups by any of three criteria. Group 1 genes (daf-11 and daf-21) are (1) strongly synergistic with group 2 genes for their Daf-c phenotype, (2) incompletely suppressed by dauer-formation defective (Daf-d) mutations in the genes daf-3 and daf-5 and (3) strongly suppressed by Daf-d mutations in nine genes that affect the structure of chemosensory endings. Group 2 genes (daf-1, daf-4, daf-7, daf-8 and daf-14) are (1) strongly synergistic with group 1 genes for their Daf-c phenotype, (2) fully suppressed by Daf-d mutations in daf-3 and daf-5 and (3) not suppressed by Daf-d mutations in the nine genes that affect chemosensory ending structure. Mutations in each group of genes also cause distinct additional behavioral defects. We propose that these two groups of Daf-c genes act in parallel pathways that process sensory information. The two pathways are partially redundant with each other and normally act in concert to control dauer formation"
Keywords:		"Animals Caenorhabditis elegans/embryology/genetics/*physiology Cloning, Molecular Larva/physiology Models, Genetic Mutation *Nervous System Physiological Phenomena Phenotype Pheromones/*physiology Suppression, Genetic;"
Notes:		"MedlineThomas, J H Birnby, D A Vowels, J J eng R35AG10917-01/AG/NIA NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1993/08/01 Genetics. 1993 Aug; 134(4):1105-17. doi: 10.1093/genetics/134.4.1105"