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J Steroid Biochem Mol Biol

Title:		Effects of endocrine disrupters on sex steroid synthesis and metabolism pathways in fish
Author(s):		Thibaut R; Porte C;
Address:		"Environmental Chemistry Department IIQAB-CSIC. C/Jordi Girona, 18, 08034 Barcelona, Spain. cpvqam@cid.csic.es"
Journal Title:		J Steroid Biochem Mol Biol
Year:		2004
Volume:		20041221
Issue:		5
Page Number:		485 - 494
DOI:		10.1016/j.jsbmb.2004.10.008
ISSN/ISBN:		0960-0760 (Print) 0960-0760 (Linking)
Abstract:		"The interactions of estrogenic (nonylphenol, dicofol, atrazine), androgenic (organotins, phthalates, fenarimol) and anti-androgenic compounds (vinclozolin, diuron, p,p'-DDE) with key enzymatic activities involved in both synthesis and metabolism of sex hormones was investigated. Carp testicular microsomes incubated in the presence of androstenedione and different xenobiotics evidenced higher sensitivity of 5alpha-reductase activity than 17beta-hydroxysteroid dehydrogenase activity towards those chemicals. Dicofol, organotins and phthalates were among the most effective inhibitors. In contrast, ovarian synthesis of maturation-inducing hormones (20alpha- and 20beta-hydroxysteroid dehydrogenase activities) were enhanced by nonylphenol, dicofol, fenarimol and p,p'-DDE. Metabolic clearance pathways of hormones were also affected. Fenarimol, nonylphenol and triphenyltin inhibited the glucuronidation of testosterone and estradiol at concentrations as low as 10, 50 and 100 microM, respectively. Triphenyltin, tributyltin and nonylphenol were also inhibitors of estradiol sulfation with IC(50) values of 17, 18 and 41 microM. Overall, the data indicates the interaction of selected chemicals with key enzymatic pathways involved in both synthesis and metabolism of sex hormones. This interference might be one of the underlying mechanisms for the reported hormonal disrupting properties of the tested compounds, and might finally affect physiological processes such as gamete growth and maturation"
Keywords:		Androstenedione/pharmacology Animals Carps/*metabolism Endocrine System/*drug effects/metabolism Female Glucuronosyltransferase/metabolism Liver/enzymology Male Microsomes/enzymology Ovary/drug effects/metabolism Sex Attractants/biosynthesis/*metabolism S;
Notes:		"MedlineThibaut, Remi Porte, Cinta eng Research Support, Non-U.S. Gov't England 2005/02/09 J Steroid Biochem Mol Biol. 2004 Dec; 92(5):485-94. doi: 10.1016/j.jsbmb.2004.10.008. Epub 2004 Dec 21"