| Title: | Accuracy of a new electronic nose for prostate cancer diagnosis in urine samples |
| Author(s): | Taverna G; Grizzi F; Tidu L; Bax C; Zanoni M; Vota P; Lotesoriere BJ; Prudenza S; Magagnin L; Langfelder G; Buffi N; Casale P; Capelli L; |
| Address: | "Department of Biomedical Sciences, Humanitas University, Milan, Italy. Department of Urology, Humanitas Mater Domini Hospital, Varese, Italy. Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Milan, Italy. Italian Ministry of Defenses, 'Vittorio Veneto' Division, Florence, Italy. Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy. Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy. Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy" |
| ISSN/ISBN: | 1442-2042 (Electronic) 0919-8172 (Print) 0919-8172 (Linking) |
| Abstract: | "OBJECTIVE: To evaluate the accuracy of a new electronic nose to recognize prostate cancer in urine samples. METHODS: A blind, prospective study on consecutive patients was designed. Overall, 174 subjects were included in the study: 88 (50.6%) in prostate cancer group, and 86 (49.4%) in control group. Electronic nose performance for prostate cancer was assessed using sensitivity and specificity. The diagnostic accuracy of electronic nose was reported as area under the receiver operating characteristic curve. RESULTS: The electronic nose in the study population reached a sensitivity 85.2% (95% confidence interval 76.1-91.9; 13 false negatives out of 88), a specificity 79.1% (95% confidence interval 69.0-87.1; 18 false positives out of 86). The accuracy of the electronic nose represented as area under the receiver operating characteristic curve 0.821 (95% confidence interval 0.764-0.879). CONCLUSIONS: The diagnostic accuracy of electronic nose for recognizing prostate cancer in urine samples is high, promising and susceptible to supplemental improvement. Additionally, further studies will be necessary to design a clinical trial to validate electronic nose application in diagnostic prostate cancer nomograms" |
| Keywords: | *Electronic Nose Humans Male Prospective Studies Prostate *Prostatic Neoplasms/diagnosis/urine ROC Curve cancer diagnosis eNose urine volatile organic compounds; |
| Notes: | "MedlineTaverna, Gianluigi Grizzi, Fabio Tidu, Lorenzo Bax, Carmen Zanoni, Matteo Vota, Paolo Lotesoriere, Beatrice Julia Prudenza, Stefano Magagnin, Luca Langfelder, Giacomo Buffi, Nicolo Casale, Paolo Capelli, Laura eng Randomized Controlled Trial Australia 2022/05/10 Int J Urol. 2022 Aug; 29(8):890-896. doi: 10.1111/iju.14912. Epub 2022 May 9" |
