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Insect Biochem Mol Biol

Title:		"Identification of a receptor type guanylyl cyclase in the antennal lobe and antennal sensory neurons of the silkmoth, Bombyx mori"
Author(s):		Tanoue S; Sumida S; Suetsugu T; Endo Y; Nishioka T;
Address:		"Laboratory of Insect Physiology, Graduate School of Agricultural Sciences, Kyoto University, Kitashirakawa, Sakyo-ku, 606-8502, Kyoto, Japan"
Journal Title:		Insect Biochem Mol Biol
Year:		2001
Volume:		31
Issue:		10
Page Number:		971 - 979
DOI:		10.1016/s0965-1748(01)00045-5
ISSN/ISBN:		0965-1748 (Print) 0965-1748 (Linking)
Abstract:		"Sensory neuron-specific guanylyl cyclases (GC), which were recently identified in rodents and nematodes, are thought to be a new family of odorant/pheromone receptors. In the antennae of the male silkmoth Bombyx mori, receptor type GC are supposed to mediate signaling of pheromone. Structure of receptor type GC expressed in insect sensory neurons has remained unidentified. Here we report the isolation of cDNA of the receptor type GC, designated BmGC-I, from the male silkmoth antennae. The deduced amino acid sequence indicates that BmGC-I appears to consist of four domains: an extracellular, single transmembrane, kinase-like and a guanylyl cyclase domain. BmGC-I is most closely related to the mammalian natriuretic peptide hormone receptor A (GC-A) and retains all the cysteine residues that are conserved within the extracellular domain of the mammalian GC-As. Transcripts of the BmGC-I gene were detected in various tissues; the flight muscles, midgut, legs, ganglion, Malpighian tubules, testis and the head. Immunohistochemical study revealed that the BmGC-I protein localizes in the antennal-lobe glomerulus and in the soma and axon of sensory neurons. We thus suggest that BmGC-I plays functional roles in the odorant information processing and the modulation of excitability in the antennal sensory neurons"
Keywords:		"Amino Acid Sequence Animals Base Sequence Bombyx/*enzymology/genetics Cloning, Molecular DNA, Complementary Genes, Insect Guanylate Cyclase/*genetics/metabolism Humans Male Molecular Sequence Data Neurons, Afferent/*metabolism RNA, Messenger/metabolism Re;"
Notes:		"MedlineTanoue, S Sumida, S Suetsugu, T Endo, Y Nishioka, T eng England 2001/08/03 Insect Biochem Mol Biol. 2001 Sep; 31(10):971-9. doi: 10.1016/s0965-1748(01)00045-5"