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Expert Rev Clin Immunol

Title:		Domestic exposure to volatile organic compounds in relation to asthma and allergy in children and adults
Author(s):		Tagiyeva N; Sheikh A;
Address:		"Institute of Applied Health Sciences, University of Aberdeen, Westburn Road Aberdeen, AB25 2ZG, UK"
Journal Title:		Expert Rev Clin Immunol
Year:		2014
Volume:		20141115
Issue:		12
Page Number:		1611 - 1639
DOI:		10.1586/1744666X.2014.972943
ISSN/ISBN:		1744-8409 (Electronic) 1744-666X (Linking)
Abstract:		"Over the past decades, the prevalence of asthma, allergic disease and atopy has increased significantly and in parallel with the increased use of products and materials emitting volatile organic compounds (VOCs) in the indoor environment. The purpose of this review is to examine the evidence of the relationship between quantitatively measured domestic exposure to VOCs and allergic diseases and allergy in children and adults. Sources, potential immune-inflammatory mechanisms and risks for development and severity of asthma and allergy have been addressed. Available evidence is based on studies that have mainly used observational designs of variable quality. Total, aromatic, aliphatic, microbial VOCs and aldehydes have been the most widely investigated VOC classes, with formaldehyde being the most commonly examined single compound. Overall, the evidence is inadequate to draw any firm conclusions. However, given indicative evidence from a few high-quality studies and significant potential for improvements in asthma outcomes in those with established disease, there is a need to consider undertaking further investigation of the relationship between domestic VOC exposure and asthma/allergy outcomes that should encompass both high-quality, robust observational studies and ultimately clinical trials assessing the impact of interventions that aim to reduce VOC exposure in children and adults with asthma"
Keywords:		Adult Asthma/*epidemiology Child Environmental Exposure/*adverse effects Female Humans Hypersensitivity/*epidemiology Male Volatile Organic Compounds/*adverse effects Voc allergic rhinitis asthma atopic eczema/dermatitis atopy formaldehyde immune response;
Notes:		"MedlineTagiyeva, Nara Sheikh, Aziz eng CZG/2/573/CSO_/Chief Scientist Office/United Kingdom Research Support, Non-U.S. Gov't Review England 2014/11/18 Expert Rev Clin Immunol. 2014 Dec; 10(12):1611-39. doi: 10.1586/1744666X.2014.972943. Epub 2014 Nov 15"