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J Cell Physiol

Title:		Cellular and molecular large-scale features of fetal adipose tissue: is bovine perirenal adipose tissue brown?
Author(s):		Taga H; Chilliard Y; Meunier B; Chambon C; Picard B; Zingaretti MC; Cinti S; Bonnet M;
Address:		"INRA, UR1213 Herbivores, Saint-Genes-Champanelle, France"
Journal Title:		J Cell Physiol
Year:		2012
Volume:		227
Issue:		4
Page Number:		1688 - 1700
DOI:		10.1002/jcp.22893
ISSN/ISBN:		1097-4652 (Electronic) 0021-9541 (Linking)
Abstract:		"Epidemiological and fetal programming studies point to the role of fetal growth in adult adipose tissue (AT) mass in large mammals. Despite the incidence of fetal AT growth for human health and animal production outcomes, there is still a lack of relevant studies. We determined the cellular and large-scale-molecular features of bovine fetal perirenal AT sampled at 110, 180, 210, and 260 days post-conception (dpc) with the aim of identifying key cellular and molecular events in AT growth. The increase in AT weight from 110 to 260 dpc resulted from an increase in adipocyte volume and particularly adipocyte number that were concomitant with temporal changes in the abundance of 142 proteins revealed by proteomics. At 110 and 180 dpc, we identified proteins such as TCP1, FKBP4, or HSPD1 that may regulate adipocyte precursor proliferation by controlling cell-cycle progression and/or apoptosis or delaying PPARgamma-induced differentiation. From 180 dpc, the up-regulation of PPARgamma-induced proteins, lipogenic and lipolytic enzymes, and adipokine expression may underpin the differentiation and increase in adipocyte volume. Also from 180 dpc, we unexpectedly observed up-regulations in the beta-subunit of ATP synthase, which is normally bypassed in brown AT, as well as in aldehyde dehydrogenases ALDH2 and ALDH9A1, which were predominantly expressed in mouse white AT. These results, together with the observed abundant unilocular adipocytes at 180 and 260 dpc, strongly suggest that fetal bovine perirenal AT has much more in common with white than with brown AT"
Keywords:		"Adipocytes/cytology/metabolism Adipogenesis Adipose Tissue, Brown/*embryology/metabolism Adipose Tissue, White/embryology/metabolism Animals Apoptosis Cattle/*embryology/metabolism Cell Count Cell Cycle Cell Differentiation Cell Proliferation Embryonic St;"
Notes:		"MedlineTaga, Hajer Chilliard, Yves Meunier, Bruno Chambon, Christophe Picard, Brigitte Zingaretti, Maria C Cinti, Saverio Bonnet, Muriel eng 2011/06/17 J Cell Physiol. 2012 Apr; 227(4):1688-700. doi: 10.1002/jcp.22893"