| Title: | Modulating role of pheromonal cues from oestrus-specific urine on 3-methylcholanthrene-induced male reproductive toxicity |
| Author(s): | Suriyakalaa U; Gayathiri R; Sankarganesh D; Kokilavani P; Sukirtha R; Ramachandran R; Kamalakkannan S; Achiraman S; |
| Address: | "Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India. Department of Zoology, Bishop Heber College, Tiruchirappalli, Tamil Nadu, India" |
| ISSN/ISBN: | 1439-0272 (Electronic) 0303-4569 (Linking) |
| Abstract: | "Polyaromatic hydrocarbons (PAHs) are persistent organic pollutants that contribute to endocrine/gonadal disruption. This study was designed to investigate the endocrine modulating role of pheromones in alleviating the reproductive toxic effects of 3-MC (3-methylcholanthrene), one of the common PAHs, in rat model. The rats were injected intraperitoneally with 3-MC at a dose of 25 mg kg(-1) BW. The serum levels of testosterone and other biochemical parameters were altered to significant levels in 3-MC-treated rats and oestrus-specific urine exposure restored all these effects to near normal. Although testis weight did not indicate any significant change, sperm and spermatid counts were significantly reduced in 3-MC-treated rats, which became normal in oestrus-urine-exposed rats. Hence, this study suggests that oestrus-specific urinary pheromones have the potential to modulate the endocrine system and alleviate the male reproductive toxic effects produced by 3-MC" |
| Keywords: | "Animals Cues Environmental Pollutants/toxicity Estrus/*urine Female Male Methylcholanthrene/*toxicity Models, Animal Rats Rats, Wistar Reproduction/*drug effects Sex Attractants/*metabolism/urine Spermatozoa/drug effects Testis/*drug effects Testosterone/;" |
| Notes: | "MedlineSuriyakalaa, U Gayathiri, R SankarGanesh, D Kokilavani, P Sukirtha, R Ramachandran, R Kamalakkannan, S Achiraman, S eng Germany 2015/12/31 Andrologia. 2016 Sep; 48(7):745-53. doi: 10.1111/and.12505. Epub 2015 Dec 29" |
