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Trends Mol Med

Title:		Exhaled Molecular Fingerprinting in Diagnosis and Monitoring: Validating Volatile Promises
Author(s):		Boots AW; Bos LD; van der Schee MP; van Schooten FJ; Sterk PJ;
Address:		"Department of Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. Electronic address: a.boots@maastrichtuniversity.nl. Department of Respiratory Medicine, Academic Medical Centre, University of Medical Centre Amsterdam, The Netherlands. Department of Respiratory Medicine, Academic Medical Centre, University of Medical Centre Amsterdam, The Netherlands; Department of Pediatric Pulmonology, Emma's Children's Hospital, Academic Medical Centre Amsterdam, The Netherlands. Department of Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands"
Journal Title:		Trends Mol Med
Year:		2015
Volume:		21
Issue:		10
Page Number:		633 - 644
DOI:		10.1016/j.molmed.2015.08.001
ISSN/ISBN:		1471-499X (Electronic) 1471-4914 (Linking)
Abstract:		"Medical diagnosis and phenotyping increasingly incorporate information from complex biological samples. This has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics). In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammatory, oxidative, microbial, and neoplastic processes. After recent proof of concept studies demonstrating moderate to good diagnostic accuracies, the latest efforts in breathomics are focused on optimization of sensor technologies and analytical algorithms, as well as on independent validation of clinical classification and prediction. Current research strategies are revealing the underlying pathophysiological pathways as well as clinically-acceptable levels of diagnostic accuracy. Implementing recent guidelines on validating molecular signatures in medicine will enhance the clinical potential of breathomics and the development of point-of-care technologies"
Keywords:		Animals *Biomarkers Exhalation Humans *Metabolomics *Molecular Diagnostic Techniques Respiration Disorders/diagnosis *Volatile Organic Compounds Breath Gc-ms diagnosis eNose metabolomics volatile organic compounds;
Notes:		"MedlineBoots, Agnes W Bos, Lieuwe D van der Schee, Marc P van Schooten, Frederik-Jan Sterk, Peter J eng Review England 2015/10/04 Trends Mol Med. 2015 Oct; 21(10):633-644. doi: 10.1016/j.molmed.2015.08.001"