| Title: | "Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4" |
| Author(s): | Sun J; Liu WK; Ellsworth C; Sun Q; Pan Y; Huang YC; Deng WM; |
| Address: | "Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA. Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA. Department of Entomology, Louisiana State University, Baton Rouge, LA 70803, USA. The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China" |
| ISSN/ISBN: | 2375-2548 (Electronic) 2375-2548 (Linking) |
| Abstract: | "Sexual attraction and perception are crucial for mating and reproductive success. In Drosophila melanogaster, the male-specific isoform of Fruitless (Fru), Fru(M), is a known master neuro-regulator of innate courtship behavior to control the perception of sex pheromones in sensory neurons. Here, we show that the non-sex-specific Fru isoform (Fru(COM)) is necessary for pheromone biosynthesis in hepatocyte-like oenocytes for sexual attraction. Loss of Fru(COM) in oenocytes resulted in adults with reduced levels of cuticular hydrocarbons (CHCs), including sex pheromones, and show altered sexual attraction and reduced cuticular hydrophobicity. We further identify Hepatocyte nuclear factor 4 (Hnf4) as a key target of Fru(COM) in directing fatty acid conversion to hydrocarbons. Fru or Hnf4 depletion in oenocytes disrupts lipid homeostasis, resulting in a sex-dimorphic CHC profile that differs from doublesex- and transformer-dependent CHC dimorphism. Thus, Fru couples pheromone perception and production in separate organs to regulate chemosensory communications and ensure efficient mating behavior" |
| Keywords: | Animals Male Drosophila melanogaster Hepatocyte Nuclear Factor 4 Lipid Metabolism Perception *Pheromones *Sex Attractants; |
| Notes: | "MedlineSun, Jie Liu, Wen-Kan Ellsworth, Calder Sun, Qian Pan, Yufeng Huang, Yi-Chun Deng, Wu-Min eng R01 CA224381/CA/NCI NIH HHS/ R01 CA227789/CA/NCI NIH HHS/ R01 GM072562/GM/NIGMS NIH HHS/ 2023/06/30 Sci Adv. 2023 Jun 30; 9(26):eadf6254. doi: 10.1126/sciadv.adf6254. Epub 2023 Jun 30" |
