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Org Biomol Chem

Title:		"Metal-free oxidative acylation/cyclization of N-methacryloyl-2-phenylbenzoimidazole with aryl aldehydes: an easy access to benzimidazo[2,1-a]isoquinolin-6(5H)-ones"
Author(s):		Boora R; Kumar GR; Subba Reddy BV;
Address:		"Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, India. basireddy@iict.res.in"
Journal Title:		Org Biomol Chem
Year:		2019
Volume:		20191031
Issue:		44
Page Number:		9627 - 9630
DOI:		10.1039/c9ob01979k
ISSN/ISBN:		1477-0539 (Electronic) 1477-0520 (Linking)
Abstract:		"A metal-free radical cyclization strategy has been developed for the synthesis of fused benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives from N-methacryloyl-2-arylbenzoimidazole and aryl aldehydes using 70% tert-butylhydroperoxide in water (TBHP). The reaction proceeds through a sequential acyl radical addition/cyclization strategy. This method is useful for the generation of biologically relevant tetracyclic scaffolds in a single-step process"
Keywords:
Notes:		"PubMed-not-MEDLINEBoora, Ramesh Kumar, G Ravi Subba Reddy, B V eng Research Support, Non-U.S. Gov't England 2019/11/02 Org Biomol Chem. 2019 Nov 28; 17(44):9627-9630. doi: 10.1039/c9ob01979k. Epub 2019 Oct 31"