| Title: | Exhaled breath compositions under varying respiratory rhythms reflects ventilatory variations: translating breathomics towards respiratory medicine |
| Author(s): | Sukul P; Schubert JK; Zanaty K; Trefz P; Sinha A; Kamysek S; Miekisch W; |
| Address: | "Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Department of Anaesthesiology and Intensive Care, University Medicine Rostock, Schillingallee 35, 18057, Rostock, Germany. pritam.sukul@uni-rostock.de. Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Department of Anaesthesiology and Intensive Care, University Medicine Rostock, Schillingallee 35, 18057, Rostock, Germany. Institute for Clinical Chemistry and Laboratory Medicine, University Clinic Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Germany" |
| DOI: | 10.1038/s41598-020-70993-0 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Control of breathing is automatic and its regulation is keen to autonomic functions. Therefore, involuntary and voluntary nervous regulation of breathing affects ventilatory variations, which has profound potential to address expanding challenges in contemporary pulmonology. Nonetheless, the fundamental attributes of the aforementioned phenomena are rarely understood and/or investigated. Implementation of unconventional approach like breathomics may leads to a better comprehension of those complexities in respiratory medicine. We applied breath-resolved spirometry and capnometry, non-invasive hemodynamic monitoring along with continuous trace analysis of exhaled VOCs (volatile organic compounds) by means of real-time mass-spectrometry in 25 young and healthy adult humans to investigate any possible mirroring of instant ventilatory variations by exhaled breath composition, under varying respiratory rhythms. Hemodynamics remained unaffected. Immediate changes in measured breath compositions and corresponding variations occurred when respiratory rhythms were switched between spontaneous (involuntary/unsynchronised) and/or paced (voluntary/synchronised) breathing. Such changes in most abundant, endogenous and bloodborne VOCs were closely related to the minute ventilation and end-tidal CO(2) exhalation. Unprecedentedly, while preceded by a paced rhythm, spontaneous rhythms in both independent setups became reproducible with significantly (P-value |
| Keywords: | "Adult Blood Gas Monitoring, Transcutaneous/methods Breath Tests/*methods Carbon Dioxide/*analysis Exhalation/*physiology Female Hemodynamics/physiology Humans Inhalation/physiology Male Mass Spectrometry Middle Aged Pulmonary Medicine *Respiration Spirome;" |
| Notes: | "MedlineSukul, Pritam Schubert, Jochen K Zanaty, Karim Trefz, Phillip Sinha, Anupam Kamysek, Svend Miekisch, Wolfram eng Research Support, Non-U.S. Gov't England 2020/08/26 Sci Rep. 2020 Aug 24; 10(1):14109. doi: 10.1038/s41598-020-70993-0" |
