| Title: | The Influence of Traffic-Related Air Pollution (TRAP) in Primary Schools and Residential Proximity to Traffic Sources on Histone H3 Level in Selected Malaysian Children |
| Author(s): | Suhaimi NF; Jalaludin J; Abu Bakar S; |
| Address: | "Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. Department of Occupational Health and Safety, Faculty of Public Health, Universitas Airlangga, Surabaya 60115, Indonesia. Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia" |
| Journal Title: | Int J Environ Res Public Health |
| ISSN/ISBN: | 1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking) |
| Abstract: | "This study aimed to investigate the association between traffic-related air pollution (TRAP) exposure and histone H3 modification among school children in high-traffic (HT) and low-traffic (LT) areas in Malaysia. Respondents' background information and personal exposure to traffic sources were obtained from questionnaires distributed to randomly selected school children. Real-time monitoring instruments were used for 6-h measurements of PM(10), PM(2.5), PM(1), NO(2), SO(2), O(3), CO, and total volatile organic compounds (TVOC). Meanwhile, 24-h measurements of PM(2.5)-bound black carbon (BC) were performed using air sampling pumps. The salivary histone H3 level was captured using an enzyme-linked immunosorbent assay (ELISA). HT schools had significantly higher PM(10), PM(2.5), PM(1), BC, NO(2), SO(2), O(3), CO, and TVOC than LT schools, all at p < 0.001. Children in the HT area were more likely to get higher histone H3 levels (z = -5.13). There were positive weak correlations between histone H3 level and concentrations of NO(2) (r = 0.37), CO (r = 0.36), PM(1) (r = 0.35), PM(2.5) (r = 0.34), SO(2) (r = 0.34), PM(10) (r = 0.33), O(3) (r = 0.33), TVOC (r = 0.25), and BC (r = 0.19). Overall, this study proposes the possible role of histone H3 modification in interpreting the effects of TRAP exposure via non-genotoxic mechanisms" |
| Keywords: | *Air Pollutants/analysis *Air Pollution/adverse effects/analysis Child Environmental Exposure/analysis Histones Humans Particulate Matter/analysis Schools histone H3 indoor air quality primary schools traffic-related air pollution vulnerable population; |
| Notes: | "MedlineSuhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili eng Research Support, Non-U.S. Gov't Switzerland 2021/08/08 Int J Environ Res Public Health. 2021 Jul 28; 18(15):7995. doi: 10.3390/ijerph18157995" |
