| Title: | Effects on airways of short-term exposure to two kinds of wood smoke in a chamber study of healthy humans |
| Author(s): | Stockfelt L; Sallsten G; Olin AC; Almerud P; Samuelsson L; Johannesson S; Molnar P; Strandberg B; Almstrand AC; Bergemalm-Rynell K; Barregard L; |
| Address: | "Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden. Leo.stockfelt@amm.gu.se" |
| DOI: | 10.3109/08958378.2011.633281 |
| ISSN/ISBN: | 1091-7691 (Electronic) 0895-8378 (Linking) |
| Abstract: | "INTRODUCTION: Air pollution causes respiratory symptoms and pulmonary disease. Airway inflammation may be involved in the mechanism also for cardiovascular disease. Wood smoke is a significant contributor to air pollution, with complex and varying composition. We examined airway effects of two kinds of wood smoke in a chamber study. MATERIALS AND METHODS: Thirteen subjects were exposed to filtered air and to wood smoke from the start-up phase and the burn-out phase of the wood-burning cycle. Levels of PM(2.5) were 295 microg/m(3) and 146 microg/m(3), number concentrations 140 000/cm(3) and 100 000/cm(3). Biomarkers in blood, breath and urine were measured before and on several occasions after exposure. Effects of wood smoke exposure were assessed adjusting for results with filtered air. RESULTS: After exposure to wood smoke from the start-up, but not the burn-out session, Clara cell protein 16 (CC16) increased in serum after 4 hours, and in urine the next morning. CC16 showed a clear diurnal variation. Fraction of exhaled nitric oxide (FENO) increased after wood smoke exposure from the burn-out phase, but partly due to a decrease after exposure to filtered air. No other airway markers increased. CONCLUSIONS: The results indicate that relatively low levels of wood smoke exposure induce effects on airways. Effects on airway epithelial permeability was shown for the start-up phase of wood burning, while FENO increased after the burn-out session. CC16 seems to be a sensitive marker of effects of air pollution both in serum and urine, but its function and the significance need to be clarified" |
| Keywords: | Adult Biomarkers Breath Tests Female Humans Inhalation Exposure/*adverse effects Lung/*drug effects/metabolism Male Malondialdehyde/metabolism Middle Aged Nitric Oxide/metabolism Oxidative Stress Particle Size Polycyclic Aromatic Hydrocarbons/analysis/*to; |
| Notes: | "MedlineStockfelt, Leo Sallsten, Gerd Olin, Anna-Carin Almerud, Pernilla Samuelsson, Lena Johannesson, Sandra Molnar, Peter Strandberg, Bo Almstrand, Ann-Charlotte Bergemalm-Rynell, Kerstin Barregard, Lars eng Clinical Trial Research Support, Non-U.S. Gov't England 2012/01/10 Inhal Toxicol. 2012 Jan; 24(1):47-59. doi: 10.3109/08958378.2011.633281" |
