| Title: | Developmental diet regulates Drosophila lifespan via lipid autotoxins |
| Author(s): | Stefana MI; Driscoll PC; Obata F; Pengelly AR; Newell CL; MacRae JI; Gould AP; |
| Address: | "The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. Alex.Gould@crick.ac.uk" |
| DOI: | 10.1038/s41467-017-01740-9 |
| ISSN/ISBN: | 2041-1723 (Electronic) 2041-1723 (Linking) |
| Abstract: | "Early-life nourishment exerts long-term influences upon adult physiology and disease risk. These lasting effects of diet are well established but the underlying mechanisms are only partially understood. Here we show that restricting dietary yeast during Drosophila development can, depending upon the subsequent adult environment, more than double median lifespan. Developmental diet acts via a long-term influence upon the adult production of toxic molecules, which we term autotoxins, that are shed into the environment and shorten the lifespan of both sexes. Autotoxins are synthesised by oenocytes and some of them correspond to alkene hydrocarbons that also act as pheromones. This study identifies a mechanism by which the developmental dietary history of an animal regulates its own longevity and that of its conspecific neighbours. It also has important implications for the design of lifespan experiments as autotoxins can influence the regulation of longevity by other factors including diet, sex, insulin signalling and population density" |
| Keywords: | "Alkenes/chemistry/*metabolism Animals Animals, Genetically Modified *Diet Drosophila melanogaster/cytology/*physiology Female Housing, Animal Insulin/metabolism Larva/growth & development Lipid Metabolism/physiology Longevity/*physiology Male;" |
| Notes: | "MedlineStefana, M Irina Driscoll, Paul C Obata, Fumiaki Pengelly, Ana Raquel Newell, Clare L MacRae, James I Gould, Alex P eng FC001088/CRUK_/Cancer Research UK/United Kingdom P40 OD018537/OD/NIH HHS/ FC001088/WT_/Wellcome Trust/United Kingdom FC001088/ARC_/Arthritis Research UK/United Kingdom 104566/Z/14/Z/WT_/Wellcome Trust/United Kingdom WT_/Wellcome Trust/United Kingdom MC_U117533887/MRC_/Medical Research Council/United Kingdom U117584237/MRC_/Medical Research Council/United Kingdom FC001088/MRC_/Medical Research Council/United Kingdom Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2017/11/11 Nat Commun. 2017 Nov 9; 8(1):1384. doi: 10.1038/s41467-017-01740-9" |
