| Title: | "Comparison of Systemic Exposure to Toxic and/or Carcinogenic Volatile Organic Compounds (VOC) during Vaping, Smoking, and Abstention" |
| Author(s): | St Helen G; Liakoni E; Nardone N; Addo N; Jacob P; Benowitz NL; |
| Address: | "Clinical Pharmacology Research Program, Division of Cardiology, Zuckerberg San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California. gideon.sthelen@ucsf.edu. Center for Tobacco Control Research and Education (CTCRE), University of California, San Francisco, California. Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Clinical Pharmacology Research Program, Division of Cardiology, Zuckerberg San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California" |
| DOI: | 10.1158/1940-6207.CAPR-19-0356 |
| ISSN/ISBN: | 1940-6215 (Electronic) 1940-6207 (Print) 1940-6215 (Linking) |
| Abstract: | "Comparisons of systemic exposure to toxicants during monitored cigarette smoking, electronic cigarette (e-cigarette) use, and abstention are needed to enhance our understanding of the risks of e-cigarette use (vaping). In a cross-over study, we measured 10 mercapturic acid metabolites of volatile organic compounds (VOCs) in 24-hour urine samples collected from 36 dual users (8 women) of e-cigarettes and cigarettes during 2 days of ad libitum vaping or cigarette-only use, and 2 days of enforced abstention. Concentrations of VOC metabolites were higher during smoking compared with vaping, except for the methylating agents' metabolite. The fold-difference in concentrations when smoking relative to vaping ranged from 1.31 (1.06-1.61; geometric mean, 95% confidence interval; 1,3-butadiene) to 7.09 (5.88-8.54; acrylonitrile). Metabolites of acrylamide [fold difference of 1.21 (1.03-1.43)] and benzene [1.46 (1.13-1.90)] were higher during vaping compared with abstention. The 1,3-butadiene and propylene oxide metabolites were higher in variable-power tank users compared with users of cig-a-likes. E-cigarettes expose users to lower levels of toxic VOCs compared with cigarette smoking, supporting their harm reduction potential among smokers. However, some e-cigarettes expose users to VOCs such as acrylamide, benzene, and propylene oxide, and may pose health risks to nonsmoking users. The results of our study will inform regulators in assessing e-cigarettes with respect to the balance between its potential harm reduction for adult smokers and risk to nonsmoking users" |
| Keywords: | Acetylcysteine/metabolism/urine Adult Carcinogens Cigarette Smoking/*adverse effects/therapy/urine Cross-Over Studies *Electronic Nicotine Delivery Systems Female Humans Male Non-Smokers Smokers Smoking Cessation/methods Tobacco Products/toxicity Vaping/*; |
| Notes: | "MedlineSt Helen, Gideon Liakoni, Evangelia Nardone, Natalie Addo, Newton Jacob, Peyton 3rd Benowitz, Neal L eng P30 DA012393/DA/NIDA NIH HHS/ R01 DA039264/DA/NIDA NIH HHS/ U54 HL147127/HL/NHLBI NIH HHS/ UL1 RR024131/RR/NCRR NIH HHS/ Comparative Study Observational Study Research Support, N.I.H., Extramural 2019/09/27 Cancer Prev Res (Phila). 2020 Feb; 13(2):153-162. doi: 10.1158/1940-6207.CAPR-19-0356. Epub 2019 Sep 25" |
