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J Hazard Mater

Title:		Integrated estrogenic effects and semi-volatile organic pollutants profile in secondary and tertiary wastewater treatment effluents in North China
Author(s):		Song J; Zhao J; Yang C; Liu Y; Yang J; Qi X; Li Z; Shao Z; Wang S; Ji M; Zhai H; Chen Z; Liu W; Li X;
Address:		"Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China. School of Environmental Science and Engineering, Tianjin University, Tianjin 300350, China. State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology (SKLUWRE, HIT), Harbin 150090, China. Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China. Electronic address: liu_wei@dlut.edu.cn. Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China. Electronic address: lixuehua@dlut.edu.cn"
Journal Title:		J Hazard Mater
Year:		2022
Volume:		20220426
Issue:
Page Number:		128984 -
DOI:		10.1016/j.jhazmat.2022.128984
ISSN/ISBN:		1873-3336 (Electronic) 0304-3894 (Linking)
Abstract:		"Endocrine-disrupting effects on aquatic organisms caused by wastewater discharging have raised extensive concerns. However, the efficiency of various wastewater treatment processes to remove estrogenic activity in effluents and the association with organic micropollutants was not well known. We evaluated the estrogenic activity using a well-characterized in vivo bioassay featuring the Chinese rare minnows (Gobiocypris rarus) and analyzed 886 semi-volatile organic compounds (SVOCs) in effluents from four secondary wastewater treatment plants (SWTP A-D) and a tertiary wastewater treatment plant (TTP E) that utilized various common treatment processes in northern China. The final effluents from SWTPs and TTP E all exhibited estrogenic effects, increasing male fish plasma vitellogenin (VTG) contents and estradiol/testosterone (E(2)/T) ratios. Key regulating genes in the male fish liver including vtg1, vtg3, era, erbeta, and cyp19a were upregulated. TTP E demonstrated high performance in reducing estrogenic activity in the effluents, with a reduction of 64% in integrative biomarkers of estrogenic response (IBR). UV disinfection at SWTPs removed IBR by 14%- 33%, while ozone disinfection at TTP E did not reduce IBR. Several SVOCs including alkanes, chlorobenzenes, and phthalates, detected at ng/L to microg/L level, significantly correlated with effluent estrogenic activity. Our findings suggest the necessity and the potential means to improve the efficiency of current wastewater treatment approaches to achieve better protection for aquatic organisms against the joint effects of mixtures of various categories of micropollutants in effluents"
Keywords:		"Animals *Cyprinidae *Environmental Pollutants Estrogens Estrone Male *Water Pollutants, Chemical/analysis/toxicity *Water Purification Disinfection Estrogenic activity Semi-volatile organic pollutants Toxicity reduction Wastewater treatment;"
Notes:		"MedlineSong, Jingyang Zhao, Jing Yang, Chen Liu, Yixin Yang, Jing Qi, Xiaojuan Li, Zechang Shao, Zheng Wang, Siyu Ji, Min Zhai, Hongyan Chen, Zhiqiang Liu, Wei Li, Xuehua eng Research Support, Non-U.S. Gov't Netherlands 2022/04/29 J Hazard Mater. 2022 Aug 5; 435:128984. doi: 10.1016/j.jhazmat.2022.128984. Epub 2022 Apr 26"