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Biochem Cell Biol

Title:		2-Undecanone alleviates asthma by inhibiting NF-kappaB pathway
Author(s):		Song G; Yu S; Zhang Y; Sun M; Zhang B; Peng M;
Address:		"Department of Pediatrics, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China"
Journal Title:		Biochem Cell Biol
Year:		2023
Volume:		20221208
Issue:		1
Page Number:		101 - 111
DOI:		10.1139/bcb-2022-0185
ISSN/ISBN:		1208-6002 (Electronic) 0829-8211 (Linking)
Abstract:		"Asthma is characterized by airway inflammation and remodeling. 2-Undecanone (methyl nonyl ketone), a volatile organic compound originating from Houttuynia cordata, has the potential to ameliorate inflammatory diseases. This study aimed to explore potential benefits of 2-undecanone in asthma. 2-Undecanone (100, 200, or 400 mg/kg) was administered intragastrically to ovalbumin (OVA)-challenged BALB/c mice. Lung tissues were collected to observe histopathological changes, and bronchoalveolar lavage fluid (BALF) was collected for the detection of inflammatory cells and cytokine production. The results showed that 2-undecanone ameliorated OVA-induced pathologic changes of lungs, including reducing inflammatory cell infiltration, goblet cell hyperplasia, and airway smooth muscle thickness. The number of inflammatory cells and the levels of IL-4, IL-5, IL-13, and IgE in BALF were decreased by 2-undecanone in asthmatic mice. Furthermore, abnormal activation of NF-kappaB pathway in lung tissues of asthmatic mice was impeded by 2-undecanone. In vitro, 2-undecanone (12.5, 25, or 50 microM) suppressed platelet-derived growth factor-BB-induced proliferation and migration of primary airway smooth muscle cells (ASMCs), and inhibited the switching of ASMCs from contractile phenotype to synthetic phenotype. Consistently, 2-undecanone blocked NF-kappaB activation in ASMCs. Collectively, 2-undecanone relieves asthma through alleviating airway inflammation and remodeling, and this beneficial effect is achieved by inhibiting NF-kappaB pathway"
Keywords:		"Animals Mice *NF-kappa B/metabolism *Asthma/chemically induced/drug therapy Ketones/adverse effects Lung/metabolism Bronchoalveolar Lavage Fluid Inflammation/pathology Mice, Inbred BALB C Disease Models, Animal 2-undecanone NF-kappaB pathway airway inflam;"
Notes:		"MedlineSong, Guihua Yu, Suping Zhang, Yan Sun, Mengmeng Zhang, Bingxue Peng, Minghao eng Canada 2022/12/09 Biochem Cell Biol. 2023 Feb 1; 101(1):101-111. doi: 10.1139/bcb-2022-0185. Epub 2022 Dec 8"