« Previous AbstractIncreased number of BrdU-labeled neurons in the rostral migratory stream of the estrous prairie vole    Next AbstractInsect Infestation Increases Viscosity of Biogenic Secondary Organic Aerosol »

Org Lett

Title:		HRMS directly from TLC slides. A powerful tool for rapid analysis of organic mixtures
Author(s):		Smith NJ; Domin MA; Scott LT;
Address:		"Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467-3860, USA"
Journal Title:		Org Lett
Year:		2008
Volume:		20080716
Issue:		16
Page Number:		3493 - 3496
DOI:		10.1021/ol8012759
ISSN/ISBN:		1523-7052 (Electronic) 1523-7052 (Linking)
Abstract:		"High-resolution mass spectra (HRMS) of individual spots on thin-layer chromatography (TLC) slides can now be obtained quickly and easily at atmospheric pressure, with zero sample preparation, using commercially available instrumentation. The method is complementary to GC-mass spectrometry but is not limited to compounds of high volatility and high thermal stability. TLC-HRMS can be used to monitor chemical reactions in real time and has the capacity thereby to accelerate significantly the pace of synthetic organic chemistry"
Keywords:		"Chromatography, Thin Layer/instrumentation/*methods Mass Spectrometry/instrumentation/*methods *Membranes, Artificial Molecular Structure Organic Chemicals/*analysis Sensitivity and Specificity;"
Notes:		"MedlineSmith, Natalie J Domin, Marek A Scott, Lawrence T eng Research Support, Non-U.S. Gov't 2008/07/17 Org Lett. 2008 Aug 21; 10(16):3493-6. doi: 10.1021/ol8012759. Epub 2008 Jul 16"