| Title: | Feeding Our Microbiota: Stimulation of the Immune/Semiochemical System and the Potential Amelioration of Non-Communicable Diseases |
| Author(s): | Smith D; Jheeta S; Fuentes HV; Palacios-Perez M; |
| Address: | "Network of Researchers on the Chemical Evolution of Life (NoRCEL), Leeds LS7 3RB, UK. Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City 04510, Mexico" |
| ISSN/ISBN: | 2075-1729 (Print) 2075-1729 (Electronic) 2075-1729 (Linking) |
| Abstract: | "Non-communicable diseases are those conditions to which causative infectious agents cannot readily be assigned. It is increasingly likely that at least some of these conditions are due to the breakdown of the previously mutualistic intestinal microbiota under the influence of a polluted, biocide-rich, environment. Following the mid-20th century African studies of Denis Burkitt, the environmental cause of conditions such as obesity has been ascribed to the absence of sufficient fibre in the modern diet, however in itself that is insufficient to explain the parallel rise of problems with both the immune system and of mental health. Conversely, Burkitt himself noted that the Maasai, a cattle herding people, remained healthy even with their relatively low intake of dietary fibre. Interestingly, however, Burkitt also emphasised that levels of non-communicable disease within a population rose as faecal weight decreased significantly, to about one third of the levels found in healthy populations. Accordingly, a more cogent explanation for all the available facts is that the fully functioning, adequately diverse microbiome, communicating through what has been termed the microbiota-gut-brain axis, helps to control the passage of food through the digestive tract to provide itself with the nutrition it needs. The method of communication is via the production of semiochemicals, interkingdom signalling molecules, potentially including dopamine. In turn, the microbiome aids the immune system of both adult and, most importantly, the neonate. In this article we consider the role of probiotics and prebiotics, including fermented foods and dietary fibre, in the stimulation of the immune system and of semiochemical production in the gut lumen. Finally, we reprise our suggestion of an ingestible sensor, calibrated to the detection of such semiochemicals, to assess both the effectiveness of individual microbiomes and methods of amelioration of the associated non-communicable diseases" |
| Keywords: | ingestible sensor microbiome microbiota microbiota-gut-brain axis non-communicable diseases prebiotics probiotics semiochemicals; |
| Notes: | "PubMed-not-MEDLINESmith, David Jheeta, Sohan Fuentes, Hannya V Palacios-Perez, Miryam eng Review Switzerland 2022/08/27 Life (Basel). 2022 Aug 5; 12(8):1197. doi: 10.3390/life12081197" |
