| Title: | The Emergence of Insect Odorant Receptor-Based Biosensors |
| Address: | "Department of Entomology, the Hebrew University of Jerusalem, Rehovot 76100, Israel. Institute of Agricultural Engineering, Agricultural Research Organization, Volcani Center, Rishon LeZion 5025001, Israel" |
| ISSN/ISBN: | 2079-6374 (Electronic) 2079-6374 (Linking) |
| Abstract: | "The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance in the fields of medicine, agriculture and public health. Insect ORs offer intrinsic amplification where a single binding event is transduced into a measurable ionic current. Consequently, insect ORs have great potential as biorecognition elements in many sensor configurations. However, integrating these sensing components onto electronic transducers for the development of biosensors has been marginal due to several drawbacks, including their lipophilic nature, signal transduction mechanism and the limited number of known cognate receptor-ligand pairs. We review the current state of research in this emerging field and highlight the use of a group of indole-sensitive ORs (indolORs) from unexpected sources for the development of biosensors" |
| Keywords: | "Animals Biosensing Techniques Insect Proteins/analysis Insecta/*metabolism Nanotubes, Carbon/chemistry Receptors, Odorant/*analysis Transducers Transistors, Electronic Volatile Organic Compounds/*chemistry bioelectronic nose biosensor carbon nanotube fiel;" |
| Notes: | "MedlineBohbot, Jonathan D Vernick, Sefi eng 1990/16/Israel Science Foundation/ Review Switzerland 2020/03/21 Biosensors (Basel). 2020 Mar 17; 10(3):26. doi: 10.3390/bios10030026" |
