| Title: | "G protein signaling in yeast: new components, new connections, new compartments" |
| Author(s): | Slessareva JE; Dohlman HG; |
| Address: | "Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, USA" |
| ISSN/ISBN: | 1095-9203 (Electronic) 0036-8075 (Linking) |
| Abstract: | "Signaling by cell surface receptors and heterotrimeric guanine nucleotide-binding proteins (G proteins) is one of the most exhaustively studied processes in the cell but remains a major focus of molecular pharmacology research. The pheromone-response system in yeast (see the Connections Map at Science's Signal Transduction Knowledge Environment) has provided numerous major advances in our understanding of G protein signaling and regulation. However, the basic features of this prototypical pathway have remained largely unchanged since the mid-1990s. New tools available in yeast are beginning to uncover new pathway components and interactions and have revealed signaling in unexpected locations within the cell" |
| Keywords: | "Cell Membrane/*metabolism Endosomal Sorting Complexes Required for Transport Endosomes/*metabolism GTP-Binding Protein alpha Subunits/metabolism GTP-Binding Protein alpha Subunits, Gq-G11 GTP-Binding Protein beta Subunits/metabolism GTP-Binding Protein ga;" |
| Notes: | "MedlineSlessareva, Janna E Dohlman, Henrik G eng P01-GM065533/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural 2006/12/02 Science. 2006 Dec 1; 314(5804):1412-3. doi: 10.1126/science.1134041" |
