| Title: | The effects of testicular trauma on fertility in the Lewis rat and comparisons to isoimmunized recipients of syngeneic sperm |
| Author(s): | Slavis SA; Scholz JN; Hewitt CW; Black KS; Campbell RS; Patel M; Zimmerman J; Peake ML; Martin DC; |
| Address: | "Department of Surgery, University of California, Irvine 92717" |
| DOI: | 10.1016/s0022-5347(17)40046-2 |
| ISSN/ISBN: | 0022-5347 (Print) 0022-5347 (Linking) |
| Abstract: | "Adult male Lewis (LEW) rats were used to investigate the effects of unilateral testicular trauma on fertility. Comparisons were made between normal and experimental rats immunized with syngeneic sperm in Complete Freund's Adjuvant (CFA). Matings within the three groups yielded offspring to all normal males, no offspring to the immunized rats, and 27% (3/11) fertility in the trauma group (p less than 0.001). The contralateral testis demonstrated decreased volumes, various degrees of aspermatogenesis and smaller seminiferous tubular diameters, in both the trauma and immunized groups compared to the controls. Similar histopathologic findings of chronic granulomatous inflammation within contralateral testes in both the trauma and immunized groups suggested a common immune etiology for infertility via possible disruption of the blood-testis barrier" |
| Keywords: | "Animals Female *Fertility *Immunization Infertility, Male/etiology/pathology Male Pregnancy Rats Rats, Inbred Lew Seminiferous Tubules/pathology Spermatogenesis Spermatozoa/*immunology Testis/*injuries/pathology;" |
| Notes: | "MedlineSlavis, S A Scholz, J N Hewitt, C W Black, K S Campbell, R S Patel, M Zimmerman, J Peake, M L Martin, D C eng Research Support, Non-U.S. Gov't 1990/03/01 J Urol. 1990 Mar; 143(3):638-41. doi: 10.1016/s0022-5347(17)40046-2" |
