| Title: | Breath Volatile Organic Compounds in Surveillance of Gastric Cancer Patients following Radical Surgical Management |
| Author(s): | Skapars R; Gasenko E; Broza YY; Sivins A; Polaka I; Bogdanova I; Pcolkins A; Veliks V; Folkmanis V; Lescinska A; Liepniece-Karele I; Haick H; Rumba-Rozenfelde I; Leja M; |
| Address: | "Institute of Clinical and Preventive Medicine, Faculty of Medicine, University of Latvia, LV-1586 Riga, Latvia. Department of Abdominal and Soft Tissue Surgery, Oncology Center of Latvia, Riga East University Hospital, LV-1038 Riga, Latvia. Department of Chemical Engineering and Russel Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 3200003, Israel" |
| DOI: | 10.3390/diagnostics13101670 |
| ISSN/ISBN: | 2075-4418 (Print) 2075-4418 (Electronic) 2075-4418 (Linking) |
| Abstract: | "As of today, there is a lack of a perfect non-invasive test for the surveillance of patients for potential relapse following curative treatment. Breath volatile organic compounds (VOCs) have been demonstrated to be an accurate diagnostic tool for gastric cancer (GC) detection; here, we aimed to prove the yield of the markers in surveillance, i.e., following curative surgical management. Patients were sampled in regular intervals before and within 3 years following curative surgery for GC; gas chromatography-mass spectrometry (GC-MS) and nanosensor technologies were used for the VOC assessment. GC-MS measurements revealed a single VOC (14b-Pregnane) that significantly decreased at 12 months, and three VOCs (Isochiapin B, Dotriacontane, Threitol, 2-O-octyl-) that decreased at 18 months following surgery. The nanomaterial-based sensors S9 and S14 revealed changes in the breath VOC content 9 months after surgery. Our study results confirm the cancer origin of the particular VOCs, as well as suggest the value of breath VOC testing for cancer patient surveillance, either during the treatment phase or thereafter, for potential relapse" |
| Keywords: | cancer follow-up gas chromatography-mass spectrometry gastric cancer nanosensors volatile organic compounds; |
| Notes: | "PubMed-not-MEDLINESkapars, Roberts Gasenko, Evita Broza, Yoav Y Sivins, Armands Polaka, Inese Bogdanova, Inga Pcolkins, Andrejs Veliks, Viktors Folkmanis, Valdis Lescinska, Anna Liepniece-Karele, Inta Haick, Hossam Rumba-Rozenfelde, Ingrida Leja, Marcis eng Switzerland 2023/05/27 Diagnostics (Basel). 2023 May 9; 13(10):1670. doi: 10.3390/diagnostics13101670" |
