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Elife

Title:		A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females
Author(s):		Boehm AC; Friedrich AB; Hunt S; Bandow P; Siju KP; De Backer JF; Claussen J; Link MH; Hofmann TF; Dawid C; Grunwald Kadow IC;
Address:		"Technical University Munich, School of Life Sciences, Neuronal Control of Metabolism, Freising, Germany. Graduate School of Systemic Neurosciences, Ludwig Maximilian University, Martinsried, Germany. ZIEL - Institute for Food and Health, Technical University Munich, School of Life Sciences, Freising, Germany. Technical University Munich, School of Life Sciences, Chair of Food Chemistry and Molecular Sensory Science, Freising, Germany. University of Bonn, Faculty of Medicine, Institute of Physiology II, Bonn, Germany"
Journal Title:		Elife
Year:		2022
Volume:		20220921
Issue:
Page Number:		-
DOI:		10.7554/eLife.77643
ISSN/ISBN:		2050-084X (Electronic) 2050-084X (Linking)
Abstract:		"Motherhood induces a drastic, sometimes long-lasting, change in internal state and behavior in many female animals. How a change in reproductive state or the discrete event of mating modulates specific female behaviors is still incompletely understood. Using calcium imaging of the whole brain of Drosophila females, we find that mating does not induce a global change in brain activity. Instead, mating modulates the pheromone response of dopaminergic neurons innervating the fly's learning and memory center, the mushroom body (MB). Using the mating-induced increased attraction to the odor of important nutrients, polyamines, we show that disruption of the female fly's ability to smell, for instance the pheromone cVA, during mating leads to a reduction in polyamine preference for days later indicating that the odor environment at mating lastingly influences female perception and choice behavior. Moreover, dopaminergic neurons including innervation of the beta'1 compartment are sufficient to induce the lasting behavioral increase in polyamine preference. We further show that MB output neurons (MBON) of the beta'1 compartment are activated by pheromone odor and their activity during mating bidirectionally modulates preference behavior in mated and virgin females. Their activity is not required, however, for the expression of polyamine attraction. Instead, inhibition of another type of MBON innervating the beta'2 compartment enables expression of high odor attraction. In addition, the response of a lateral horn (LH) neuron, AD1b2, which output is required for the expression of polyamine attraction, shows a modulated polyamine response after mating. Taken together, our data in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit"
Keywords:		Animals Calcium Dopamine Dopaminergic Neurons/physiology *Drosophila/physiology *Drosophila Proteins/metabolism Drosophila melanogaster/physiology Female Mushroom Bodies/physiology Odorants Pheromones Polyamines Smell/physiology D.melanogaster Drosophila;neuroscience;
Notes:		"MedlineBoehm, Ariane C Friedrich, Anja B Hunt, Sydney Bandow, Paul Siju, K P De Backer, Jean Francois Claussen, Julia Link, Marie Helen Hofmann, Thomas F Dawid, Corinna Grunwald Kadow, Ilona C eng Research Support, Non-U.S. Gov't England 2022/09/22 Elife. 2022 Sep 21; 11:e77643. doi: 10.7554/eLife.77643"