| Title: | Colorimetric chromophoric rapid detection of SARS-CoV-2 through breath analysis |
| Author(s): | Sheikh HK; Arshad T; Habib U; Mohammad ZS; Ahmed Siddiqui MU; Hassan M; |
| Address: | "Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan. Department of Applied Chemistry, University of Karachi, Karachi, Pakistan. Research Centre for Modelling and Simulation, National University of Scientist and Technology, Islamabad, Pakistan. Health Sciences, Riphah International University, Islamabad, Pakistan" |
| ISSN/ISBN: | 1011-601X (Print) 1011-601X (Linking) |
| Abstract: | "Early and rapid detection of SARS-CoV-2 in an infected person is one fundamental part of the strategy against the spread of this virus. As of now, the usual practice is to carry out polymerase chain reaction (PCR) test which provides results in 24-48 hours. Hence, there exists a crucial need for rapid and immediate screening of people suspected to be infected. Presence of volatile organic compounds (VOCs) in the exhaled breath can be one such prospect for detection of virus. In this paper, we have designed chromophoric adducts of VOC's in the exhaled breath that can be formed for colorimetric detection of SARS-CoV-2. We noted the bathochromic shift in lambda (nm) of VOC molecules upon chromophore formation for colorimetric detection. If adapted, this research work will result in low cost solution to the requirement of immediate detection of SARS-CoV-2, hence cost and time of testing will be reduced, compared to PCR and antibodies tests. Also VOC's detection in early stage of infection where symptoms are not visible can be advantageous" |
| Keywords: | Breath Tests/*methods COVID-19 Testing/*methods Colorimetry/*methods Humans Volatile Organic Compounds/analysis; |
| Notes: | "MedlineSheikh, Hamdullah Khadim Arshad, Tanzila Habib, Uzma Mohammad, Zainab Sher Ahmed Siddiqui, Maaz Uddin Hassan, Mohtasheemul eng Pakistan 2022/03/01 Pak J Pharm Sci. 2022 Jan; 35(1):157-160" |
