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Fungal Genet Biol

Title:		The inhibition of mating in Phycomyces blakesleeanus by light is dependent on the MadA-MadB complex that acts in a sex-specific manner
Author(s):		Shakya VPS; Idnurm A;
Address:		"Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, USA; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, USA. Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, USA; School of BioSciences, University of Melbourne, Australia. Electronic address: alexander.idnurm@unimelb.edu.au"
Journal Title:		Fungal Genet Biol
Year:		2017
Volume:		20170216
Issue:
Page Number:		20 - 30
DOI:		10.1016/j.fgb.2017.02.005
ISSN/ISBN:		1096-0937 (Electronic) 1087-1845 (Linking)
Abstract:		"Light is an environmental signal that influences reproduction in the Mucoromycotina fungi, as it does in many other species of fungi. Mating in Phycomyces blakesleeanus is inhibited by light, but the molecular mechanisms for this inhibition are uncharacterized. In this analysis, the role of the light-sensing MadA-MadB complex in mating was tested. The MadA-MadB complex is homologous to the Neurospora crassa White Collar complex. Three genes required for cell type determination in the sex locus or pheromone biosynthesis are transcriptionally-regulated by light and are controlled by MadA and MadB. This regulation acts through the plus partner, indicating that the inhibitory effect of light on mating is executed through only one of the two sexes. These results are an example whereby the mating types of fungi have acquired sex-specific properties beyond their role in conferring cell-type identity, and provide insight into how sex-determining chromosomal regions can expand the traits they control"
Keywords:		"Genes, Mating Type, Fungal/*genetics/radiation effects Light Neurospora crassa/genetics/growth & development Pheromones/genetics Phycomyces/*genetics/growth & development/radiation effects *Sex Characteristics Blue light sensing HMG-domain Mating type loc;"
Notes:		"MedlineShakya, Viplendra P S Idnurm, Alexander eng 2017/02/20 Fungal Genet Biol. 2017 Apr; 101:20-30. doi: 10.1016/j.fgb.2017.02.005. Epub 2017 Feb 16"