| Title: | "Genomic, Molecular, and Phenotypic Characterization of Arthrobacter sp. OVS8, an Endophytic Bacterium Isolated from and Contributing to the Bioactive Compound Content of the Essential Oil of the Medicinal Plant Origanum vulgare L" |
| Author(s): | Semenzato G; Del Duca S; Vassallo A; Bechini A; Calonico C; Delfino V; Berti F; Vitali F; Mocali S; Frascella A; Emiliani G; Fani R; |
| Address: | "Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Italy. Council for Agricultural Research and Economics, Research Centre for Agriculture and Environment, Via di Lanciola 12/A, 50125 Cascine del Riccio, Italy. School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano 1, 62032 Camerino, Italy. Department of Health Sciences, University of Florence, viale G.B. Morgagni, 48, 50134 Firenze, Italy. Institute for Sustainable Plant Protection (IPSP)-National Research Council (CNR), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy" |
| ISSN/ISBN: | 1422-0067 (Electronic) 1422-0067 (Linking) |
| Abstract: | "Medicinal plants play an important role in the discovery of new bioactive compounds with antimicrobial activity, thanks to their pharmacological properties. However, members of their microbiota can also synthesize bioactive molecules. Among these, strains belonging to the genera Arthrobacter are commonly found associated with the plant's microenvironments, showing plant growth-promoting (PGP) activity and bioremediation properties. However, their role as antimicrobial secondary metabolite producers has not been fully explored. The aim of this work was to characterize the Arthrobacter sp. OVS8 endophytic strain, isolated from the medicinal plant Origanum vulgare L., from molecular and phenotypic viewpoints to evaluate its adaptation and influence on the plant internal microenvironments and its potential as a producer of antibacterial volatile molecules (VOCs). Results obtained from the phenotypic and genomic characterization highlight its ability to produce volatile antimicrobials effective against multidrug-resistant (MDR) human pathogens and its putative PGP role as a producer of siderophores and degrader of organic and inorganic pollutants. The outcomes presented in this work identify Arthrobacter sp. OVS8 as an excellent starting point toward the exploitation of bacterial endophytes as antibiotics sources" |
| Keywords: | "Humans *Oils, Volatile/pharmacology *Plants, Medicinal/microbiology *Origanum *Arthrobacter Anti-Bacterial Agents/pharmacology Endophytes/metabolism Genomics endophytes essential oil genome plant microbiota volatile organic compounds;" |
| Notes: | "MedlineSemenzato, Giulia Del Duca, Sara Vassallo, Alberto Bechini, Angela Calonico, Carmela Delfino, Vania Berti, Fabiola Vitali, Francesco Mocali, Stefano Frascella, Angela Emiliani, Giovanni Fani, Renato eng Switzerland 2023/03/12 Int J Mol Sci. 2023 Mar 2; 24(5):4845. doi: 10.3390/ijms24054845" |
